Allergy and the lung

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii29
Academic Journal
Atopic preschoolers differ in both prognosis and in response to inhaled corticosteroids. Skin prick testing by estimating allergic sensitization may therefore help inform clinical management. Mast cells play a central role in the pathogenesis of many diverse diseases including asthma, pulmonary fibrosis and mastocyfosis. Ion channels are involved in many cell processes including proliferation and apoptosis. Human lung mast cells and peripheral blood-derived mast cells express the intermediate conductance activated channel IKCA, which opens following IgE-dependent activation and which enhances degranulation.


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