TITLE

Pulmonary epithelium in health and disease

PUB. DATE
December 2003
SOURCE
Thorax;Dec2003 Supplement 3, Vol. 58, piii26
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In an attempt to circumvent the topical barriers to gene transfer such as mucus and sputum, researchers have determined ii airway epithelial cells can be transfected through systemic delivery of "naked" oligonucleotides (ODNs). ODNs are potentially relevant to CF in the context of gene repair-down-regulation of genes involved in the pathogenic process. Acute exposure to altitudes of 3800-4500 m results in hyperpolarization of the transepitheliol nasal potential difference, a surrogate measure for distal respiratory epithelium ion transport. This hyperpolarization normalises within days if subjects remain at the same altitude. No data exist on longer term, exposure to increasing altitudes above.
ACCESSION #
12965182

 

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