Asthma: mechanisms of inflammation

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii15
Academic Journal
Vascular endothelial growth factor is highly expressed in the airways of asthmatic patients, and correlates with increased mipcosal vascularity. Current techniques of measuring airway inflammation in asthma such as induced sputom and single flow nitric oxide concentration are limited to sanjpling of the proximal airways. The development of a two compartment !odel of pulmonary nitric oxide production has allowed a non invasive estimation of alveolar nifric oxide concentration. Mast cells inliltrate the bronchial epithelium in asthma placing them at the portal of entry of noxious stimuli. Human lung mast cells adhere avidly to bronchial epithelial monolayers in vitro.


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