TITLE

COPD: mechanisms of disease progression

PUB. DATE
December 2003
SOURCE
Thorax;Dec2003 Supplement 3, Vol. 58, piii10
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Neutrophilic inflammation is thought to be central to both the terminal airspace enlargement and airway narrowing that characterizes chronic obstructive pulmonary disease (COPD). Retinoids are derivatives of vitamin A and include the biologically active metabolite, retinoic acid (RA). Mammals are unable to synthesize retinoids de novo and are entirely dependent on an adequate dietary intake. Endoqenous RA signalling is required for normal postnatal alveolar devejopment. The development of COPD in a minority of smokers has been attributed to a greatly accelerated rate of decline in FEV.
ACCESSION #
12965169

 

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