COPD: mechanisms of disease progression

December 2003
Thorax;Dec2003 Supplement 3, Vol. 58, piii10
Academic Journal
Neutrophilic inflammation is thought to be central to both the terminal airspace enlargement and airway narrowing that characterizes chronic obstructive pulmonary disease (COPD). Retinoids are derivatives of vitamin A and include the biologically active metabolite, retinoic acid (RA). Mammals are unable to synthesize retinoids de novo and are entirely dependent on an adequate dietary intake. Endoqenous RA signalling is required for normal postnatal alveolar devejopment. The development of COPD in a minority of smokers has been attributed to a greatly accelerated rate of decline in FEV.


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