TITLE

BTS/BLF Young Investigators Prize Symposium

PUB. DATE
December 2003
SOURCE
Thorax;Dec2003 Supplement 3, Vol. 58, piii1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Agonist stimulation of the human b2-adrenoceptor increases intracellular cAMP and downstream cAMP response element (CRE) mediated gene transcription. This study was conducted to determine whether long and short acting agonists stimulate different degrees of CRE-gene transcription. Neutrophilic inflammation is central to the pathogenesis of a wide variety of pulmonary diseases including ARDS. Alveolar epithelial cell contribute to neutrophilic inflammation by increased cell surface expression of adhesion molecules, for example, intercellular adhesion molecule and release of chemokines and cytokines. Thioredoxin, an intracellular redox active protein, regulates the activity of cellular enzymes and transcription factors.
ACCESSION #
12965163

 

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