December 2001
Thorax;Dec2001 Supp, Vol. 56, piii52
Academic Journal
This article presents various studies related to bronchiectasis and transplantation. The "vicious cycle" hypothesis for bronchiectasis predicts that persistent bacterial colonization of the airway perpetuates inflammatory changes and prevents clearance of these bacteria and their damaging pro-inflammatory mediators. The evidence shows a small but limited benefit for prolonged antibiotics in bronchiectasis. Further randomized controlled trials with adequate power and standardized end-points are required.


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