December 2001
Thorax;Dec2001 Supp, Vol. 56, piii44
Academic Journal
This article presents various studies that explore the relation between basic science and cyctic fibrosis. Pulmonary inflammation in Cystic Fibrosis is characterised by continual influx of neutrophils from the bloodstream. Depending on the chemoattractant stimulus, neutrophils can migrate to the lung by two pathways-one which depends on the b2 integrin family of adhesion molecules and one that is CD18-independent. Nitric oxide (NO) is a signalling molecule with antimicrobial activity. Cystic fibrosis respiratory epithelial cells have reduced expression of the inducible isoform of NO synthase and show increased susceptibility to Pseudomonas aeruginosa infection.


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