December 2001
Thorax;Dec2001 Supp, Vol. 56, piii5
Academic Journal
This article presents various studies related to scientific aspects of lung fibrosis. According to a study. Interferon-gamma (IFN-y), a Thi cytokine, may attenuate the decline in lung function in patients with idiopathic pulmonary fibrosis. These effects may be partly mediated by decreased transforming growth factor-13 production by the alveolar macrophage. However, the effect of IFN-y on interleukin-8 production by the alveolar epithelium is unclear. Pulmonary fibrosis is characterised by excessive deposition of extracellular matrix proteins within the lung parenchyma. Activation of the coagulation cascade is an important feature of this condition and levels of thrombin are increased in bronchoalveolar lavage fluid from both patients and in animal models of this disorder.


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