TITLE

Male germ cells and photoreceptors, both dependent on close cell-cell interactions, degenerate upon ClC-2 Cl- channel disruption

AUTHOR(S)
Bösl, Michael R.; Stein, Valentin; Hübner, Christian; Zdebik, Anselm A.; Jordt, Sven-Eric; Mukhopadhyay, Amal K.; Davidoff, Michail S.; Holstein, Adolf-Friedrich; Jentsch, Thomas J.
PUB. DATE
March 2001
SOURCE
EMBO Journal;3/15/2001, Vol. 20 Issue 6, p1289
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The functions of some CLC Cl- channels are evident from human diseases that result from their mutations, but the role of the broadly expressed ClC-2 Cl- channel is less clear. Several important functions have been attributed to ClC-2, but contrary to these expectations ClC-2-deficient mice lacked overt abnormalities except for a severe degeneration of the retina and the testes, which led to selective male infertility. Seminiferous tubules did not develop lumina and germ cells failed to complete meiosis. Beginning around puberty there was a massive death of primary spermatocytes and later also of spermatogonia. Tubules were filled with abnormal Sertoli cells, which normally express ClC-2 in patches adjacent to germ cells. In the retina, photoreceptors lacked normal outer segments and degenerated between days P10 and P30. The current across the retinal pigment epithelium was severely reduced at P36. Thus, ClC-2 disruption entails the death of two cell types which depend on supporting cells that form the blood-testes and blood-retina barriers. We propose that ClC-2 is crucial for controlling the ionic environment of these cells.
ACCESSION #
12954977

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics