TITLE

Altered Cellular Distribution of Tuberin and Glucocorticoid Receptor in Sporadic Fundic Gland Polyps

AUTHOR(S)
Wei, Jianjun; Chiriboga, Luis; Yee, Herman; Mizuguchi, Masashi; Li, Eric; Sidhu, Gurdip S.; West, A. Brian
PUB. DATE
August 2002
SOURCE
Modern Pathology;Aug2002, Vol. 15 Issue 8, p862
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Gastric fundic gland polyps (FGPs) are considered hamartomas, and various gastrointestinal hamartomas are associated with tuberous sclerosis complex (TSC). The aim of this study was to investigate a possible link between TSC proteins (hamartin and tuberin) and sporadic FGPs. We examined 33 sporadic FGPs and 26 biopsies of normal fundic mucosa by immunohistochemistry. Nuclear immunoreactivity for tuberin was dramatically reduced or lost in most sporadic FGPs, and tuberin unexpectedly accumulated in the cytoplasm in oxyntic glands. About 18% (6/33) of FGPs were immunopositive in an average of 1.7% of oxyntic cell nuclei, compared with 77% (20/26) of controls in an average of 24.4% of oxyntic cell nuclei (P < .01). No change in hamartin was noted. We further examined the tuberin-associated proteins glucocorticoid receptor (GCR) and p27. Nuclear immunoreactivity for GCR was lost in most sporadic FGPs, but p27 distribution was normal. Sporadic FGPs had a low frequency of staining for Ki-67 except for some cells from cystic components, which is consistent with their slow growth. Our results are consistent with the hypothesis that tuberin may play an important role in pathogenesis of sporadic FGPs. First, an altered cellular localization of tuberin may lead to the deregulation of cell proliferation by interrupting its interaction with hamartin. Second, altered cellular localization of tuberin may preclude its negative regulation of gene transcription mediated by GCR.
ACCESSION #
12954480

 

Related Articles

  • Potential mechanism for the effects of dexamethasone on growth of human melanoma cells in vitro. Osman, Abdel-Moneim M.; Nasseir, Omimah A.; Ismail, Naglaa R. // Health (1949-4998);Aug2010, Vol. 2 Issue 8, p857 

    This study deals with the inhibitory effects of dexamethsone on the proliferation of a human melanoma cell line in vitro. A retarded cell proliferation was observed in M-5A cells with the presence of specific high affinity glucocorticoid steroid receptors. There was a correlation between the...

  • A Single-Day Treatment with Mifepristone Is Sufficient to Normalize Chronic Glucocorticoid Induced Suppression of Hippocampal Cell Proliferation. Pu Hu; Oomen, Charlotte; Van Dam, Anne-Marie; Wester, Jordi; Jiang-Ning Zhou; Joéls, Marian; Lucassen, Paul J. // PLoS ONE;Sep2012, Vol. 7 Issue 9, Special section p1 

    Background: Chronic stress or prolonged administration of glucocorticoids suppresses proliferation and/or survival of newborn cells in adult rat dentate gyrus. Earlier we showed that administration of the glucocorticoid receptor antagonist mifepristone during the final 4 days of a 21 days period...

  • Anti-tumor efficacy of fulvestrant in estrogen receptor positive gastric cancer. Yi, Jun Ho; Do, In-Gu; Jang, Jiryeon; Kim, Seung Tae; Kim, Kyoung-Mee; Park, Se Hoon; Park, Joon Oh; Park, Young Suk; Lim, Ho Yeong; Kang, Won Ki; Lee, Jeeyun // Scientific Reports;12/26/2014, p7592 

    To investigate the prognostic role of the estrogen receptor (ER) in gastric cancer (GC) patients, tumor tissues from 932 patients with advanced GC were assessed for ER expression using immunohistochemistry, and their clinicopathologic features were evaluated. Forty patients (4.3%) had ER...

  • Gastric bare area and left adrenal gland involvement on abdominal computed tomography and their prognostic value in acute pancreatitis. Liu, Zaiyi; Yan, Zhihan; Min, Pengqiu; Liang, Changhong; Wang, Ying // European Radiology;Aug2008, Vol. 18 Issue 8, p1611 

    To demonstrate the CT manifestations of gastric bare area involvement (GBAI) and left adrenal gland involvement (LAGI) in acute pancreatitis (AP) and evaluate their prognostic value. From January 2003 to December 2006, CT examinations of 116 patients with AP were retrospectively reviewed. There...

  • Ablation of paternal accessory sex glands is detrimental to embryo development during implantation. Jiang, H. Y.; O, W. S.; Lee, K. H.; Tang, P. L.; Chow, P. H. // Anatomy & Embryology;Apr2001, Vol. 203 Issue 4, p255 

    The accessory sex glands are present in most mammals, but their function(s) have not yet been clearly defined. In the golden hamster, removal of all the glands or the ventral prostate alone have been shown to considerably reduce fertility, while the effect is milder if the ampullary glands only...

  • Indefinite for non-invasive neoplasia lesions in gastric intestinal metaplasia: the immunophenotype. Cassaro, Mauro; Rugge, Massimo; Tieppo, Chiara; Giacomelli, Luciano; Velo, Daniela; Nitti, Donato; Farinati, Fabio // Journal of Clinical Pathology;Jun2007, Vol. 60 Issue 6, p615 

    Background: In the Padova International Classification, gastric precancerous lesions are labelled as "indefinite for non-invasive neoplasia" (Indef-NiN) cytohistological alterations mimicking non-invasive neoplasia (NiN), but lacking all the attributes required for a definite NiN categorisation....

  • The Incidence of Lymphoplasmacytic Gastritis in the Fundus and Antrum of Cynomolgus Monkey (Macaca fascicularis) Stomachs. McKeag, Sean; McInnes, Elizabeth F. // Journal of Toxicologic Pathology;2012, Vol. 25 Issue 4, p249 

    Lymphoplasmacytic gastritis is a concern for toxicological pathologists reading preclinical, non-human primate toxicity studies because subtle gastric changes which could be treatment-related may be masked and gastritis lesions may be confused with treatment-related effects and thus a gastric...

  • cytostatic.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p574 

    A definition of the term "cytostatic" is presented, which refers to a state that prevents cell growth and cell proliferation.

  • Hemangiopericytoma in a female dog with direct invasion of abdominal cavity and pulmonary metastasis. da Silva, Elisângela Olegário; Romero, Fernanda; Thandile Green, Kerriel; Mello Martins, Maria Isabel; Rodrigues Loureiro Bracarense, Ana Paula Frederico // Ciência Rural;fev2014, Vol. 44 Issue 2, p358 

    An intact adult female Poodle dog was presented with a history of an increase in volume in the left and right mammary inguinal glands. The histopathological examination revealed a proliferation of spindle cells arranged in bundles with concentric arrangements surrounding blood vessels,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics