Supplementation of a bovine milk formula with an oligosaccha ride mixture increases counts of faecal bifidobacteria in preterm infants

Boehm, G.; Lidestri, M.; Casetta, P.; Jelinek, J.; Negretti, F.; Stahl, B.; Marini, A.
May 2002
Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2002, Vol. 86 Issue 3, pF178
Academic Journal
Background: The establishment of a balanced intestinal microflora which may protect against infection is desirable for the preterm infant. Objective: To investigate the effect of a preterm formula milk supplement consisting of oligosaccharides in similar proportions to human milk on the faecal flora and stool characteristics of preterm infants. Study design: To resemble the effect of human milk, an oligosaccharide mixture consisting of 90% galacto-oligosaccharides and 10% fructo-oligosaccharides was used to supplement a standard preterm formula at a concentration of 10 g/l. This supplemented formula was studied in 15 preterm infants, and the results were compared with those found in 1 5 infants fed a formula supplemented with maltodextrin as placebo. A group fed fortified mother's milk was investigated as a reference group (n = 12). On four days during a 28 day feeding period (1, 7, 14, and 28), the faecal flora was investigated, and stool characteristics, growth, and possible side effects were recorded. Results: During the study period, the number of bifidobacteria in the group fed the oligosaccharide supplemented formula increased to the upper range of bifidobacteria counts in the reference group. The difference between the supplemented and non-supplemented groups was highly significant (p = 0.0008). The stool characteristics were also influenced by the supplement: the stool frequency after 28 days was significantly lower in the control group than in the oligosaccharide supplemented group (p = 0.0079) and the reference group (p < 0.0001). Over the study period, the stool consistency in the control group became harder, but remained fairly stable in the other two groups. There was no effect of the different diets on the incidence of side effects (crying, regurgitation, vomiting) or on weight gain or length gain. Conclusion: Supplementing preterm formula with a mixture of galacto- and fructo-oligosaccharides at a concentration of 10 g/l stimulates the growth of bifidobacteria in the intestine and results in stool characteristics similar to those found in preterm infants fed human milk. Therefore prebiotic mixtures such as the one studied may help to improve intestinal tolerance to enteral feeding in preterm infants.


Related Articles

  • Randomised, double blind trial of oxytocin nasal spray in mothers expressing breast milk for preterm infants. Fewtrell, M. S.; Loh, K. L.; Blake, A.; Ridout, D. A.; Hawdon, J. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2006, Vol. 91 Issue 3, pF169 

    Background: Human milk has considerable short and long term benefits for preterm infants, but mothers may experience difficulties in expressing breast milk for infants too immature or sick to breast feed. Oxytocin has been used to assist breast feeding and milk expression, but few data are...

  • Cooperation of β-galactosidase and β-N-acetylhexosaminidase from bifidobacteria in assimilation of human milk oligosaccharides with type 2 structure. Miwa, Mika; Horimoto, Tomohiro; Kiyohara, Masashi; Katayama, Takane; Kitaoka, Motomitsu; Ashida, Hisashi; Yamamoto, Kenji // Glycobiology;Nov2010, Vol. 20 Issue 11, p1402 

    Bifidobacteria are predominant in the intestines of breast-fed infants and offer health benefits to the host. Human milk oligosaccharides (HMOs) are considered to be one of the most important growth factors for intestinal bifidobacteria. HMOs contain two major structures of core tetrasaccharide:...

  • Tips from Other Journals. CRAWFORD-FAUCHER, AMY // American Family Physician;7/1/2010, Vol. 82 Issue 1, p78 

    The article discusses research on the use of domperidone to increase breast milk. It references the study "Effect of Domperidone on the Composition of Preterm Human Breast Milk," by M. L. Campbell-Yeo et al. published in the January 2010 issue of "Pediatrics." It involved mothers who delivered...

  • Two distinct α-l-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates. Ashida, Hisashi; Miyake, Akiko; Kiyohara, Masashi; Wada, Jun; Yoshida, Erina; Kumagai, Hidehiko; Katayama, Takane; Yamamoto, Kenji // Glycobiology;Sep2009, Vol. 19 Issue 9, p1010 

    Bifidobacteria are predominant bacteria present in the intestines of breast-fed infants and offer important health benefits for the host. Human milk oligosaccharides are one of the most important growth factors for bifidobacteria and are frequently fucosylated at their non-reducing termini....

  • Donor Human Milk for Preterm Infants. Wight, Nancy E // Journal of Perinatology;Jun2001, Vol. 21 Issue 4, p249 

    As survival rates for preterm infants improve, more attention is being focused on improving the quality of survival through optimal nutritional management. The benefits of human milk for term infants are well recognized, with current research suggesting that human milk may especially benefit the...

  • Human milk and the preterm baby. Williams, A.F. // BMJ: British Medical Journal (International Edition);6/19/93, Vol. 306 Issue 6893, p1628 

    Compares the nutrient components of human milk and specialized formulas for preterm babies in Great Britain. Determination of the health requirements of low birthweight infants; Difference between feeding and nutrition; Analysis on the antimicrobial and trophic properties of the human milk.

  • Share your liquid assets. HORTON, MARY JANE // Fit Pregnancy;Jun/Jul2012, Vol. 19 Issue 2, p18 

    The article focuses on donated breast milk, which can be useful for pre-mature babies as their mothers may not be able to produce milk initially.

  • A quantitative and comprehensive method to analyze human milk oligosaccharide structures in the urine and feces of infants. De Leoz, Maria; Wu, Shuai; Strum, John; Niñonuevo, Milady; Gaerlan, Stephanie; Mirmiran, Majid; German, J.; Mills, David; Lebrilla, Carlito; Underwood, Mark // Analytical & Bioanalytical Chemistry;May2013, Vol. 405 Issue 12, p4089 

    Human milk oligosaccharides (HMOs), though non-nutritive to the infant, shape the intestinal microbiota and protect against pathogens during early growth and development. Infant formulas with added galacto-oligosaccharides have been developed to mimic the beneficial effects of HMOs. Premature...

  • The human milk oligosaccharide disialyllacto-N-tetraose prevents necrotising enterocolitis in neonatal rats. Jantscher-Krenn, Evelyn; Zherebtsov, Monica; Nissan, Caroline; Goth, Kerstin; Guner, Yigit S.; Naidu, Natasha; Choudhury, Biswa; Grishin, Anatoly V.; Ford, Henri R.; Bode, Lars // Gut;Oct2012, Vol. 61 Issue 10, p1417 

    Background Necrotising enterocolitis (NEC) is one of the most common and fatal intestinal disorders in preterm infants. Breast-fed infants are at lower risk for NEC than formula-fed infants, but the protective components in human milk have not been identified. In contrast to formula, human milk...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics