Phenobarbitone, neonatal seizures, and video-EEG

Boylan, G. B.; Rennie, J. M.; Pressler, R. M.; Wilson, G.; Morton, M.; Binnie, C. D.
May 2002
Archives of Disease in Childhood -- Fetal & Neonatal Edition;May2002, Vol. 86 Issue 3, pF165
Academic Journal
Aims: To evaluate the effectiveness of phenobarbitone as an anticonvulsant in neonates. Methods: An observational study using video-EEG telemetry. Video-EEG was obtained before treatment was started, for an hour after treatment was given, two hours after treatment was given, and again between 1 2 and 24 hours after treatment was given. Patients were recruited from all babies who required phenobarbitone (20-40 mg/kg intravenously over 20 minutes) for suspected clinical seizures and had EEG monitoring one hour before and up to 24 hours after the initial dose. An EEG seizure discharge was defined as a sudden repetitive stereotyped discharge lasting for at least 10 seconds. Neonatal status epilepticus was defined as continuous seizure activity for at least 30 minutes. Seizures were categorised as EEG seizure discharges only (electrographic), or as EEG seizure discharges with accompanying clinical manifestations (electroclinical). Surviving babies were assessed at one year using the Griffiths neurodevelopmental score. Results: Fourteen babies were studied. Four responded to phenobarbitone; these had normal or moderately abnormal EEG background abnormalities and outcome was good. In the other 10 babies electrographic seizures increased after treatment, whereas electroclinical seizures reduced. Three babies were treated with second line anticonvulsants, of whom two responded. One of these had a normal neurodevelopmental score at one year, but the outcome for the remainder of the whole group was poor. Conclusion: Phenobarbitone is often ineffective as a first line anticonvulsant in neonates with seizures in whom the background EEG is significantly abnormal.


Related Articles

  • Take these actions for elder seizures.  // ED Nursing;Apr2010, Vol. 13 Issue 6, p65 

    The article presents suggestions by several medical practitioners regarding the emergency treatment for seizures in older patients. Education specialist Patricia Sciscione recommends that anticonvulsants and intubation medications should be administered to secure healthy respiratory status....

  • Influence of retigabine on the anticonvulsant activity of some antiepileptic drugs against audiogenic seizures in DBA/2 mice. De Sarro, Giovambattista; Di Paola, Eugenio Donato; Conte, Giuseppe; Pasculli, Maria Patrizia; De Sarro, Angela // Naunyn-Schmiedeberg's Archives of Pharmacology;Mar2001, Vol. 363 Issue 3, p330 

    Retigabine (D-2319, 0.5–20 mg/kg i.p.) antagonised dose dependently audiogenic seizures in DBA/2 mice. Retigabine at 0.5 mg/kg i.p., a dose that per se did not affect the occurrence of audiogenic seizures significantly, potentiated the anticonvulsant activity of carbamazepine, diazepam,...

  • Anticonvulsant and sodium channel blocking activity of higher doses of clenbuterol. Fischer, W.; Kittner, H.; Regenthal, R.; Malinowska, B.; Schlicker, E. // Naunyn-Schmiedeberg's Archives of Pharmacology;Feb2001, Vol. 363 Issue 2, p182 

    Clenbuterol, a lipophilic β2-adrenoceptor agonist, was investigated in various seizure models of experimental epilepsy. In the maximal electroshock seizure threshold test, clenbuterol (≥4 mg/kg i.p.) increased the electroconvulsive threshold for tonic seizures in mice. In the...

  • Questions and Answers. Dreifuss, Fritz E.; Yaffe, Sumner J. // JAMA: Journal of the American Medical Association;4/4/90, Vol. 263 Issue 13, p1844 

    Addresses questions related to medicine. Development of sensory-evoked seizures in a physician; Long-term effects of anticonvulsant exposure.

  • gabapentin.  // Royal Society of Medicine: Medicines;2002, p261 

    The article presents information on gabapentin. The drug is an anticonvulsant and anti-epileptic drug. It can be used as an adjunct to assist in the control of partial seizures that have not responded to other anti-epileptic drugs. Administration is oral. Side effects include: fatigue,...

  • EVOLUTION OF EPILEPSY. TATUM IV, WILLIAM O.; KAPLAN, PETER W.; JALLON, PIERRE // Epilepsy A to Z: A Concise Encyclopedia;2009, p127 

    An encyclopedia entry for the evolution or progression of epilepsy is presented. This entry identifies several patterns that predict the progression of epilepsy, including single seizures, either acutely symptomatic or cryptogenic. It suggests to establish the syndromic classification and...

  • PREGABALIN (LYRICA). TATUM IV, WILLIAM O.; KAPLAN, PETER W.; PIERRE, JALLON // Epilepsy A to Z: A Concise Encyclopedia;2009, p264 

    An encyclopedia entry for "Pregabalin® (Lyrica)" is presented. It is an antiepileptic drug that binds with high affinity to the alpha2-delta subunit of voltage-gated calcium channels in the central nervous system. It is similar to gabapentin which also has a linked to animal evidence of...

  • The clinical conundrum of neonatal seizures. Levene, M. // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Mar2002, Vol. 86 Issue 2, pF75 

    There is increasing evidence that neonatal seizures have an adverse effect on neurodevelopmental progression and may predispose to cognitive, behavioural, or epileptic complications later in life. However, given the uncertainty about the efficacy and toxicity of the commonly used...

  • Sedated Newborns.  // Pediatrics for Parents;Sep/Oct2011, Vol. 27 Issue 9/10, p17 

    The article focuses on the study regarding the effect of oxycodone for breastfed infants compared with codeine that leads to neonatal central nervous system (CNS) depression.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics