Effect of salt supplementation of newborn premature infants on neurodevelopmental outcome at 10-13 years of age

Al-Dahhan, J.; Jannoun, L.; Haycock, G. B.
March 2002
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Mar2002, Vol. 86 Issue 2, pF120
Academic Journal
Background: The nutritional requirements of prematurely born infants are different from those of babies born at term. Inadequate or inappropriate dietary intake in the neonatal period may have long term adverse consequences on neurodevelopmental function. The late effect of neonatal sodium deficiency or repletion in the premature human infant on neurological development and function has not been examined, despite evidence in animals of a serious adverse effect of salt deprivation on growth of the central nervous system. Methods: Thirty seven of 46 children who had been born prematurely (gestational age of 33 weeks or less) and allocated to diets containing 1-1.5 mmol sodium/day (unsupplemented) or 4-5 mmol sodium/day (supplemented) from the 4th to the 14th postnatal day were recalled at the age of 10-1 3 years. Detailed studies of neurodevelopmental performance were made, including motor function and assessment of intelligence (IQ), memory and learning, language and executive skills, and behaviour. Sixteen of the children were found to have been in the supplemented group and 21 in the unsupplemented group. Results: Children who had been in the supplemented group performed better in all modalities tested than those from the unsupplemented group. The differences were statistically significant (analysis of variance) for motor function, performance IQ, the general memory index, and behaviour as assessed by the children's parents. The supplemented children outperformed the unsupplemented controls by 10% in all three components of the memory and learning tests (difference not significant but p < 0. 1 for each) and in language function (p < 0.05 for object naming) and educational attainment (p < 0.05 for arithmetic age). Conclusions: Infants born at or before 33 weeks gestation require a higher sodium intake in the first two weeks of postnatal life than those born at or near term, and failure to provide such an intake (4-5 mmol/day) may predispose to poor neurodevelopmental outcome in the second decade of life.


Related Articles

  • Key research on feeding of premature vulnerable babies.  // Infant;May2012, Vol. 8 Issue 3, p97 

    The article reports on the findings of a study published in the journal "Pediatrics" which focuses on the vulnerabilities in feeding premature babies in Great Britain.

  • AMP-activated protein kinase in the brain. Ronnett, G. V.; Aja, S. // International Journal of Obesity;Sep2008 Supplement 4, Vol. 32, pS42 

    Since its discovery as an important regulator of fuel utilization in the periphery, AMP-activated protein kinase (AMPK) has become a contender for many important cell-intrinsic and organismal roles regarding energy balance in the central nervous system. The challenge will be to delineate the...

  • Space-time clustering of childhood central nervous system tumours in Yorkshire, UK.  // BMC Cancer;2012, Vol. 12 Issue 1, p13 

    The article discusses a study which performed space-time clustering of childhood central nervous system (CNS) tumours in Yorkshire, England. The study extracted information on individuals aged 0-14 years, diagnosed with a CNS tumour between the January 1, 1974 and December 31, 2006 from the...

  • Load and Order in Rapid Automatized Naming: A Large-Scale Prospective Study of Toddlers With Brain Injury. Geva, Ronny; Gardner, Judith M.; Karmel, Bernard Z. // Journal of Cognitive Education & Psychology;2010, Vol. 9 Issue 2, p166 

    The rapid automatized naming task (RAN) is a well-established tool to evaluate risk of developmental disorders. Its potential use with 3-year-olds who are at risk for learning difficulties and factors affecting its dependent measures are not yet understood. This study investigated the effects of...

  • Attention problems and language development in preterm low-birth-weight children: Crosslagged relations from 18 to 36 months.  // BMC Pediatrics;2011, Vol. 11 Issue 1, p59 

    The article presents information on a study conducted on attention problems and language development in preterm low-birth-weight children. It is stated that preterm birth may affect brain development because the central nervous system of the premature infant is not fully prepared. It was found...

  • Neoplasias astrocíticas en la edad pediátrica: casuística del Hospital Universitario Dr. José E González. Alvarado-Bernal, Yuridia Lizeth; Fuentes-Reyes, Rodolfo A.; Rosa, Guillermo García-de la; Morales-Cuéllar, Carolina; Ancer-Arellano, Adriana; Barboza-Quintana, Oralia; Ancer-Rodríguez, Jesús; Miranda-Maldonado, Ivett C. // Patologia Revista Latinoamericana;oct-dic2009, Vol. 47 Issue 4, p327 

    Background: The astrocytic neoplasms are the most frequent primary tumors of the central nervous system (CNS) in children. They are classified according to their histology and grade of the malignancy since they are considered an entity with different biological behavior that requires...

  • One-Year Outcome of Auditory-Tactile-Visual-Vestibular Intervention in the Neonatal Intensive Car... Nelson, Michael N.; White-Traut, Rosemary C.; Vasan, Ushanalini; Silvestri, Jean; Comiskey, Elizabeth; Meleedy-Rey, Patricia; Littau, Susan; Guoguang Gu; Patel, Minu // Journal of Child Neurology;Jul2001, Vol. 16 Issue 7, p493 

    Examines the one-year outcome of a multisensory intervention in infants with severe prematurity and central nervous system injury. Association of periventricular leukomalacia with poorer mental development; Exhibition of better motor and mental performance in experimental infants; Assessment of...

  • Population pharmacokinetics of micafungin in neonates and young infants.  // Journal of Invasive Fungal Infections;2010, Vol. 4 Issue 3, p124 

    Hematogenous Candida meningoencephalitis is a frequent complication of candidial infections in premature infants. It has been postulated that micafungin would be an effective treatment in this setting; however, the pharmacokinetics of micafungin at the required doses have not been adequately...

  • Neurovirological methods and their applications. Kennedy P G E; Kennedy, P G E // Journal of Neurology, Neurosurgery & Psychiatry;Aug2003, Vol. 74 Issue 8, p1016 

    Over the last 30 years neurovirology has emerged as a major discipline which has much relevance to both human disease and many aspects of neuroscience. This overview of the field aims to define briefly most of the major neurovirological techniques, both "classical" and more recent, and to...


Read the Article


Sign out of this library

Other Topics