TITLE

Sex dependent differences in physiological ageing in the immune system of lower airways in healthy non-smoking volunteers: study of lymphocyte subsets in bronchoalVeolar lavage fluid and blood

AUTHOR(S)
Mund, B.; Christensson, B.; Larsson, K.; Grönneberg, R.
PUB. DATE
June 2001
SOURCE
Thorax;Jun2001, Vol. 56 Issue 6, p450
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background-Age related changes in the immune system have been studied frequently but a possible relation to sex has not, to our knowledge, previously been examined. The effect of age and sex on the composition of lymphocyte subsets in bronchoalveolar lavage (BAL) fluid and peripheral blood was therefore examined. Methods-Bronchoscopy with lavage was performed in 32 healthy non-atopic, non- smoking volunteers (16 women aged 26-63 years (mean 44) and 16 men aged 23-63 years (mean 39)). Cytospin preparations for differential counts of BAL fluid cells and surface antigen expression of lymphocytes from BAL fluid and blood were analysed by flow cytometry. AT Results-Most parameters in the HAL fluid changed with age in women. The percentage of CD4+ lymphocytes increased with age from a mean of 48 (SD10)% in women aged ⩽40 years to 69 (11)% in women aged >43 years (p0.001). The percentage of CD8+ lymphocytes tended to decrease with age and the CD4/CD8 ratio was 5.8 (1.2) in women aged >43 years compared with 2.1 (0.7) in those aged ⩽40 years (p<0.0001). Women aged >43 years differed from men aged >43 years as well as from younger subjects of both sexes with respect to CD4+ cells and CD4/CD8 ratio, and from younger women with respect to CD8+ cells. There was no age related change in the CD4/CD8 ratio in blood. No sex related differences were seen in the blood or BAL fluid of adults below the age of 40 years. Conclusions-The composition of lymphocytes with different phenotypes in the lower respiratory tract changes with age in women but not in men. This may have implications for some clinical conditions such as chronic dry cough which are observed predominantly in women.
ACCESSION #
12941028

 

Related Articles

  • CD8+ T lymphocytes in bronchoalveolar lavage in idiopathic pulmonary fibrosis. Papiris, Spyros A.; Kollintza, Androniki; Karatza, Marilena; Manali, Effrosyni D.; Sotiropoulou, Christina; Milic-Emili, Joseph; Roussos, Charis; Daniil, Zoe // Journal of Inflammation;2007, Vol. 4, p1 

    Background: Recently it was shown that in Idiopathic Pulmonary Fibrosis (IPF) tissue infiltrating CD8+ T lymphocytes (TLs) are associated with breathlessness and physiological indices of disease severity, as well as that CD8+ TLs recovered by bronchoalveolar lavage (BAL) relate to those...

  • Exhaled 8-isoprostane in sarcoidosis: relation to superoxide anion production by bronchoalveolar lavage cells. Piotrowski, Wojciech; Kurmanowska, Zofia; Antczak, Adam; Marczak, Jerzy; Ciebiada, Maciej; Górski, Paweł // Inflammation Research;Dec2010, Vol. 59 Issue 12, p1027 

    Objective: This study was designed to examine the mutual relationship between 8-isoprostane in exhaled breath condensate (EBC) and superoxide anion generation by bronchoalveolar lavage fluid (BALF) cells in patients with sarcoidosis. Design: About 29 patients with sarcoidosis, 34 healthy never...

  • Inflammatory markers in bronchoalveolar lavage fluid from human volunteers 2 hours after hydrogen fluoride exposure. Lund, K.; Dunster, C.; Ramis, I.; Sandström, T.; Kelly, F. J.; Søstrand, P.; Schwarze, P.; Skovlund, E.; Boe, J.; Kongerud, J.; Refsnes, M. // Human & Experimental Toxicology;Mar2005, Vol. 24 Issue 3, p101 

    Fluoride has been in focus as a possible causal agent for respiratory symptoms amongst aluminium potroom workers for several decades. Previously, using bronchoalveolar lavage (BAL), we demonstrated airway inflammation in healthy volunteers 24 hours after exposure to hydrogen fluoride (HF). The...

  • Local CD4+, CD8+ and CD56+ T-lymphocite Reaction on Primary Lung Cancer. Jusufovic, Edin; Prnjavorac, Besim; Iljazovic, Ermina; Kosnik, Mitja; Keser, Dragan; Korosec, Peter; Stahov, Jugoslav; Zukic, Edin; Sejdinovic, Rifat; Ajanovic, Ekrem // Acta Informatica Medica;2011, Vol. 19 Issue 3, p132 

    Objective: The primary goal of this study was to determine the difference of abundance of CD4+, CD8+ and CD56+ bronchoalveolar fluid's lymphocytes and their subpopulations between cancerous lung and healthy lung from the same patient. Methods: Mini-bronchoalveolar lavage was taken from 55...

  • CD4/CD8 ratio and cytokine levels of the BAL fluid in patients with bronchiectasis caused by sulfur mustard gas inhalation. Emad, Ali; Emad, Yasaman // Journal of Inflammation;2007, Vol. 4, p2 

    Objective: To analyze cytokine levels in BAL fluid of patients with bronchiectasis due to mustard gas inhalation. Patients: 29 victims with mustard gas-induced bronchiectasis and 25 normal veterans as control group. Intervention: PFTs,, high-resolution CT scans of the chest, analyses of BAL...

  • Local CD4+, CD8+ and CD56+ reactions to lung cancer in regard to pathohistological type and clinical stage. Jusufovic, Edin; Iljazovic, Ermina; Kosnik, Mitja; Keser, Dragan; Korosec, Peter; Zukic, Edin; Prnjavorac, Besim; Sejdinović, Rifat; Ajanović, Ekrem // Medicinski Glasnik;Feb2011, Vol. 8 Issue 1, p101 

    No abstract available.

  • Análise do lavado broncoalveolar em vítimas de queimaduras faciais graves. Rabello, Eucir; Batista, Vera Flores; Lago, Patrícia Martins; Alvares, Renata de Azevedo Gameiro; Martinusso, Cesônia de Assis; Lapa e Silva, José Roberto // Jornal Brasileiro de Pneumologia;apr2009, Vol. 35 Issue 4, p343 

    To analyze bronchoalveolar lavage (BAL) specimens of burn victims who inhaled smoke, in order to identify alterations associated with mortality or survival. Methods: Eighteen victims of facial burns were submitted to BAL up to 24 h after the event. We investigated cell and protein content,...

  • Proliferative Response of Bronchoalveolar Lymphocytes to Beryllium. Rossman, Milton D.; Kern, Jeffrey A.; Elias, Jack A.; Cullen, Mark R.; Epstein, Paul E.; Preuss, Otto P.; Markham, Thomas N.; Daniele, Ronald P. // Annals of Internal Medicine;May88, Vol. 108 Issue 5, p687 

    Presents a study which determined whether the proliferative response of bronchoalveolar lymphocytes to beryllium salts is useful for diagnosing chronic beryllium disease. Methods; Results; Discussion.

  • Protection against Bronchiolitis Obliterans Syndrome Is Associated with Allograft CCR7+CD45RA― T Regulatory Cells. Gregson, Aric L.; Hoji, Aki; Palchevskiy, Vyacheslav; Hu, Scott; Weigt, S. Samuel; Liao, Eileen; Derhovanessian, Ariss; Saggar, Rajeev; Song, Sophie; Elashoff, Robert; Yang, Otto O.; Belperio, John A. // PLoS ONE;2010, Vol. 5 Issue 6, p1 

    Bronchiolitis obliterans syndrome (BOS) is the major obstacle to long-term survival after lung transplantation, yet markers for early detection and intervention are currently lacking. Given the role of regulatory T cells (Treg) in modulation of immunity, we hypothesized that frequencies of Treg...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics