TITLE

Dendritic cells in the mucosa of the human trachea are not regularly found in the first year of life

AUTHOR(S)
Tschernig, T.; Debertin, A. S.; Paulsen, F.; Kleemann, W. J.; Pabst, R.
PUB. DATE
June 2001
SOURCE
Thorax;Jun2001, Vol. 56 Issue 6, p427
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background-Dendritic cells (DCs) in the mucosa of the respiratory tract might be involved in the early development of pulmonary allergy or tolerance. To date, little is known about when the first DCs occur in human airways. Methods-Specimens of the distal trachea from patients who had died from sudden death in the first year of life (n=29) and in older age groups (n=59) as well as from those who had died from respiratory tract infections in the first year of life (n=8) were examined by immunohistochemistry. Transmission electron microscopy was performed in additional samples from two adults. Results-In the sudden death subgroup DCs were absent in 76% of those who died in the first year of life but were present in 53 of the 59 older cases. All infants who had died of respiratory infectious diseases had DCs in the tracheal mucosa. Conclusions-Mature DCs are not constitutively present in the human tracheobronchial mucosa in the first year of life, but their occurrence seems to be triggered by infectious stimuli. These data support the hypothesis that DCs play a crucial role in immunoregulation in early childhood.
ACCESSION #
12941024

 

Related Articles

  • Density of dendritic cells in the human tracheal mucosa is age dependent and site specific. Tschernig, T.; de Vries, V. C.; Debertin, A. S.; Braun, A.; Walles, T.; Traub, F.; Pabst, R. // Thorax;Nov2006, Vol. 61 Issue 11, p986 

    Background: The mucosal immune system undergoes extensive changes in early childhood in response to environmental stimuli. Dendritic cells (DC) play a major role in the development of the immune system. However, few data exist on the influence of continuous environmental stimulation on the...

  • In this Issue.  // Mucosal Immunology (1933-0219);Jul2013, Vol. 6 Issue 4, p655 

    An introduction is presented in which the editor discusses various reports within the issue on topics including mucosal immunity in HIV, fibrocytes recruitment in asthma, and lung dendritic cells migration.

  • tracheocele.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2346 

    A definition of the term "tracheocele," which refers to the protrusion of mucous membrane through the wall of the trachea, is presented.

  • Pulmonary Effects of Oxygen Breathing. Sackner, Marvin A.; Landa, Jose; Hirsch, Judith // Annals of Internal Medicine;Jan75, Vol. 82 Issue 1, p40 

    Presents a study of ten normal volunteers that confirmed the animal experiments showing that exposure to oxygen damages the tracheal mucosa as found by measurements of tracheal mucous velocity. Materials and methods; Results of the study.

  • Antigen-presenting Cells in Human Radicular Granulomas. Kaneko, T.; Okiji, T.; Kaneko, R.; Nör, J. E.; Suda, H. // Journal of Dental Research;Jun2008, Vol. 87 Issue 6, p553 

    Substantial numbers of dendritic cells have been detected in radicular granulomas. To test the hypothesis that local antigen presentation from dendritic cells to T-cells is involved critically in immunological responses within radicular granulomas, we compared characteristics of dendritic cells...

  • Esophageal acid exposure still plays a major role in patients with NERD. Savarino, Edoardo; Zentilin, Patrizia; Savarino, Vincenzo // Journal of Gastroenterology;Apr2013, Vol. 48 Issue 4, p552 

    No abstract available.

  • Relevance of Ultrastructural Alterations of Intercellular Junction Morphology in Inflamed Human Esophagus. Chia-Chin Liu; Jeng Woei Lee; Tso-Tsai Liu; Chih-Hsun Yi; Chien-Lin Chen // Journal of Neurogastroenterology & Motility;Jul2013, Vol. 19 Issue 3, p324 

    Background/Aims Detailed characterization of the ultrastructural morphology of intercellular space in gastroesophageal reflux disease has not been fully studied. We aimed to investigate whether subtle alteration in intercellular space structure and tight junction proteins might differ among...

  • Videostroboscopic and morphological aspects of voice disturbances in patients with larynx atrophy and coexisting hypopharynx cancer. Kosztyła-Hojna, Bożena; Andrzejewska, Anna; Moskal, Diana; Kasperuk, Joanna; Falkowski, Dawid; Rogowski, Marek // Folia Histochemica et Cytobiologica;2011, Vol. 49 Issue 4, p659 

    Vocal folds play a crucial role in voice production. The physiological vibrations of vocal folds depend on the unchanged multilayered structure of the vocal folds mucosa. Morphological changes of mucosa are the cause of voice quality disorders - dysphonia. The aim of this study was to determine...

  • Distribution of Langerhans Cells in Normal and Carcinogen-Treated Mucosa of Buccal Pouches of Hamsters. Schwartz, Joel; Solt, Dennis B.; Pappo, Jacques; Weichselbaum, Ralph // Journal of Dermatologic Surgery & Oncology;Dec81, Vol. 7 Issue 12, p1005 

    The distribution of Langerhans cells in normal and carcinogen-treated mucosa of buccal pouches of hamsters was studied. Decrease in density and in focal aggregates of Langerhans cells and loss of their complex dentritic networks were found in carcinogen-treated mucosa.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics