Dietrich, C. G.; Geier, A.; Elferink, R. P. J. Oude
December 2003
Gut;Dec2003, Vol. 52 Issue 12, p1788
Academic Journal
Detoxification of xenobiotics, including toxins, carcinogens, and drugs, is the central task of many metabolising enzymes in the body. Two groups of enzymes are known to handle metabolism of harmful compounds. The group of cytochrome P450 isoenzymes (CYPs) comprises numerous isoforms leading to oxidation mostly hydroxylation of molecules. Isoforms in the CYP groups 1, 2, and 3 mediate metabolism of many exogenous compounds. Many toxins and carcinogens require activation by CYP45O isoenzymes to obtain their reactive properties in the body. Because CYP45O isoenzymes mostly catalyse the first step of biotransformation, this function is called phase I metabolism.


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