TITLE

ABC OF ORAL BIOAVAILABILITY: TRANSPORTERS AS GATEKEEPERS IN THE GUT

AUTHOR(S)
Dietrich, C. G.; Geier, A.; Elferink, R. P. J. Oude
PUB. DATE
December 2003
SOURCE
Gut;Dec2003, Vol. 52 Issue 12, p1788
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Detoxification of xenobiotics, including toxins, carcinogens, and drugs, is the central task of many metabolising enzymes in the body. Two groups of enzymes are known to handle metabolism of harmful compounds. The group of cytochrome P450 isoenzymes (CYPs) comprises numerous isoforms leading to oxidation mostly hydroxylation of molecules. Isoforms in the CYP groups 1, 2, and 3 mediate metabolism of many exogenous compounds. Many toxins and carcinogens require activation by CYP45O isoenzymes to obtain their reactive properties in the body. Because CYP45O isoenzymes mostly catalyse the first step of biotransformation, this function is called phase I metabolism.
ACCESSION #
12940924

 

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