From comic relief to real understanding; how intestinal gas causes symptoms

Quigley, E. M. M.
December 2003
Gut;Dec2003, Vol. 52 Issue 12, p1659
Academic Journal
Gas content and transit appear to conspire with the motor and sensory responses of the gut to produce gas related symptoms, both in normal individuals and especially in irritable bowel syndrome (IBS) patients. Gas retention in the small intestine, an organ poorly prepared for this event, is more likely to cause symptoms, especially in an individual who exhibits visceral hypersensitivity. The studies indicate that distension is a real phenomenon in lBS and that such distension accurately reflects gas content. More problematic is extrapolation of the observations relating symptoms to gas transit and retention.


Related Articles

  • Modulation of Intestinal Gas Dynamics in Healthy Human Volunteers by the 5-HT4 Receptor Agonist Tegaserod. Coleski, Radoslav; Chung Owyang; Hasler, William L. // American Journal of Gastroenterology;Aug2006, Vol. 101 Issue 8, p1858 

    OBJECTIVES: Bloating in irritable bowel syndrome (IBS) may result from impaired intestinal gas transit and is reduced by the 5-HT4 agonist tegaserod. Abnormal serotonergic function underlies many IBS symptoms, but the role of 5-HT4 pathways in regulating gas dynamics under healthy conditions is...

  • Impaired Small Bowel Gas Propulsion in Patients with Bloating During Intestinal Lipid Infusion. Salvioli, Beatrice; Serra, Jordi; Azpiroz, Fernando; Malagelada, Juan-R. // American Journal of Gastroenterology;Aug2006, Vol. 101 Issue 8, p1853 

    OBJECTIVE: In healthy individuals, intraluminal lipids delay intestinal gas clearance, and this reflex is exaggerated in patients with irritable bowel syndrome (IBS). Our aim was to determine the site of action of abnormal lipid-induced reflexes in IBS. METHODS: In six patients with (IBS)...

  • A Strategy for Management of the Irritable Bowel. Thompson, W. Grant // American Journal of Gastroenterology;Feb1986, Vol. 81 Issue 2, p95 

    Presents research which discussed a medical technique for management of the irritable bowel syndrome. Efficiency of sigmoidoscopy in detecting the disease; Information on drugs used in the treatment of the syndrome; Importance of harmonious physician-patient relationship to the recovery of...

  • Prevalence and risk factors for abdominal bloating and visible distention: a population-based study. Jiang, X.; Locke III, G. H.; Choung, A. S.; Zinsmeister, A. A.; Schleck, C. D.; Talley, N. J. // Gut;Jun2008, Vol. 57 Issue 6, p756 

    Background: Abdominal bloating and visible distention are common yet poorly understood symptoms. Epidemiological data distinguishing visible distention from bloating are not available. We aimed to evaluate the prevalence and potential risk factors for abdominal bloating and visible distention...

  • Hypothesis Driven Research and Molecular Mechanisms in Functional Dyspepsia: The Beginning of a Beautiful Friendship in Research and Practice? Holtmann, Gerald; Talley, Nicholas J. // American Journal of Gastroenterology;Mar2006, Vol. 101 Issue 3, p593 

    There is accumulating evidence of a genetic predisposition in at least a subset of patients with functional GI symptoms. Hence, hunting for genes in irritable bowel syndrome and functional dyspepsia has become fashionable of late. Unfortunately, as in other fields, replication of gene...

  • Isogel.  // Royal Society of Medicine: Medicines;2002, p309 

    The article presents information on isogel, a proprietary, non-prescription preparation of the (bulking-agent) laxative ispaghula husk. It can be used to treat a number of gastrointestinal disorders, including irritable bowel syndrome, and is available as granules.

  • Food Allergy and the Irritable Bowel Syndrome. Zwetchkenbaum, John F.; Burakoff, Robert // American Journal of Gastroenterology;Sep1988, Vol. 83 Issue 9, p901 

    Discusses recent literature on food allergy, and its possible role in the irritable bowel syndrome. Definition of food allergy; Diagnosis of food hypersensitivity; Tests that use food extracts in assessing Immunoglobulin E-mediated food hypersensitivity.

  • FOOD ALLERGY 'LINK' TO BOWEL PAIN. Berriman, Mark; Fraser, Robert // New Vegetarian & Natural Health;Spring2005, p11 

    Presents the results of a study suggesting that irritable bowel syndrome (IBS) may be linked to allergic reactions to common foods. Periodical where the study was published; Level of antibodies of IBS patients to wheat, beef and soya beans.

  • IBS - allergy - and the perception of pain.  // Foods Matter (USA);Mar2008, p16 

    The article reports on various studies related to the irritable bowel syndrome (IBS), allergy and the perception of pain. One study found that the likelihood of IBS was significantly high in patients with seasonal allergic rhinitis and allergic eczema. Another research suggests that the brains...


Read the Article


Sign out of this library

Other Topics