TITLE

Hypothesis on the pathophysiology of syringomyelia based on simulation of cerebrospinal fluid dynamics

AUTHOR(S)
Chang, H. S.; Nakagawa, H.
PUB. DATE
March 2003
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Mar2003, Vol. 74 Issue 3, p344
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objectives: Despite many hypotheses, the pathophysiology of syringomyelia is still not well understood. In this report, the authors propose a hypothesis based on analysis of cerebrospinal fluid dynamics in the spine.Methods: An electric circuit model of the CSF dynamics of the spine was constructed based on a technique of computational fluid mechanics. With this model, the authors calculated how a pulsatile CSF wave coming from the cranial side is propagated along the spinal cord.Results: Reducing the temporary fluid storage capacity of the cisterna magna dramatically increased the pressure wave propagated along the central canal. The peak of this pressure wave resided in the mid-portion of the spinal cord.Conclusions: The following hypotheses are proposed. The cisterna magna functions as a shock absorber against the pulsatile CSF waves coming from the cranial side. The loss of shock absorbing capacity of the cisterna magna and subsequent increase of central canal wall pressure leads to syrinx formation in patients with Chiari I malformation.
ACCESSION #
12940756

 

Related Articles

  • Analysis of cerebrospinal fluid flow dynamics and morphology in Chiari I malformation with cine phase-contrast magnetic resonance imaging. Wang, Cheng-Shi; Wang, Xing; Fu, Chu-Hua; Wei, Lu-Qing; Zhou, Dai-Quan; Lin, Jiang-Kai // Acta Neurochirurgica;Apr2014, Vol. 156 Issue 4, p707 

    Background: To determine cerebrospinal fluid (CSF) dynamics and morphology in Chiari I malformation (CMI) and assess the response to surgery of the posterior cranial fossa, we examined midsagittal imaging along with anterior cervical 2-3 (AC2-3), posterior cervical 2-3 (PC2-3), and aqueduct CSF...

  • Duraplasty or not? An evidence-based review of the pediatric Chiari I malformation. Hankinson, Todd; Tubbs, R. Shane; Wellons, John C. // Child's Nervous System;Jan2011, Vol. 27 Issue 1, p35 

    Objectives: Few studies are available that directly compare dural opening with and without additional intradural maneuvers. Therefore, the current review analyzed the available literature regarding this topic. Methods: An Ovid MEDLINE search was completed using each of the terms 'Chiari...

  • Volume change theory for syringimyelia: A new perspective. Survendra Kumar Rajdeo Rai; Pooja Survendra Kumar Rai // Asian Journal of Neurosurgery;Oct-Dec2015, Vol. 10 Issue 4, p245 

    Background: The etiopathogenesis of syringomyelia is still an enigma. The authors present a novel theory based on fluid dynamics at the craniovertebral (CV) junction to explain the genesis of syringomyelia (SM). The changes in volume of spinal canal, spinal cord, central canal and spinal...

  • Syringomyelia: Cavities in the Spinal Cord. Huls, Jessica // World & I;Nov2006, Vol. 21 Issue 10, p9 

    The article provides information on syringomyelia, a progressive disorder of the spinal cord. The condition usually causes chronic pain in the back while at the same time causing an inability to feel pain and temperature in other parts of the body. The cerebrospinal fluid is a clear, water-like...

  • Theoretical analysis of the pathophysiology of syringomyelia associated with adhesive arachnoiditis. Chang, H. S.; Nakagawa, H. // Journal of Neurology, Neurosurgery & Psychiatry;May2004, Vol. 75 Issue 5, p754 

    Objective: To apply a theoretical model to analyse the derangement of cerebrospinal fluid (CSF) dynamics in syringomyelia associated with adhesive arachnoiditis.Methods: An electrical circuit model of CSF dynamics in the spine was used. With this model, the derangement...

  • Foramen magnum decompression for the treatment of Arnold Chiari malformation type I with associated syringomyelia in an elderly patient. Takigami, I.; Miyamoto, K.; Kodama, H.; Hosoe, H.; Tanimoto, S.; Shimizu, K. // Spinal Cord;Apr2005, Vol. 43 Issue 4, p249 

    STUDY DESIGN::Report of a rare case of an elderly patient with late onset of Arnold Chiari malformation type I with associated syringomyelia that was successfully treated with foramen magnum decompression. OBJECTIVE::To report this rare case along with a literature review. SETTING:: Gifu, Japan....

  • Syringomyelia with Chiari malformation; 3 unusual cases with implications for pathogenesis. Owler, B. K.; Halmagyi, G. M.; Brennan, J.; Besser, M. // Acta Neurochirurgica;Oct2004, Vol. 146 Issue 10, p1137 

    Syringomyelia is an important cause of neurological deficit. Most cases of non-traumatic syringomyelia occur in association with a Chiari malformation. We present three unusual examples of syringomyelia with such an association. The first case is that of syringomyelia in a young woman with...

  • Chiari Malformation and Syringomyelia. Snyder, Pamela // Radiologic Technology;Jul/Aug2008, Vol. 79 Issue 6, p555 

    The article explores the mechanism of syringomyelia formation with Chiari I malformation. It discusses several types of Chiari malformation, stresses the most common ways that describe the different types of syringomyelia, and highlights pathogenesis concerning the biomechanics of both diseases....

  • Disfagia orofaringea asociada con malformación de Chiari tipo l y siringomielia. Cortés-Medina, Julio César; Cárdenas-Lara, Armando; Guerrero-Rascón, Carlos Alberto; Rodríguez-Bautista, Heber // Cirugia y Cirujanos;may/jun2014, Vol. 82 Issue 3, p309 

    Background: Dysphagia associated with neurological disease is an important clinical manifestation in the diagnosis of injury that justifies the compression of the brainstem and lower cranial nerves. Objective: To emphasize the study of dysphagia in a patient with Chiari I malformation associated...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics