Airway function at one year: association with premorbid airway function, wheezing, and maternal smoking

Dezateux, C.; Stocks, J.; Wade, A. M.; Dundas, I.; Fletcher, M. E.
September 2001
Thorax;Sep2001, Vol. 56 Issue 9, p680
Academic Journal
Background-Impaired growth and development of the respiratory system during fetal and early postnatal life may have important implications for lung development and later lung health. The aim of this study was to examine the association of diminished premorbid airway function, prior wheezing, and maternal smoking with airway function at 1 year of age. Methods--Respiratory function was measured at the end of the first year in 100 of 108 healthy term infants (93%) in whom similar measurements had been undertaken prior to any respiratory illness at 8 weeks. Physician diagnosed wheezing episodes were identified retrospectively from medical records. Results--At 1 year specific airway conductance during end expiration (sGawEE; /s/kPa) was significantly diminished in those infants with prior wheezing (95% CI wheeze/no wheeze -0.76 to -0.14), mothers who smoked (95% CI smoke/no smoke -0.81 to -0.27), a family history of asthma (95% CI family history/no family history -0.62 to 0.00), or diminished premorbid sGawEE (95% CI -0.13 to -0.431s/kPa per unit reduction sGawEE at 8 weeks). In a multivariate model only maternal smoking and diminished premorbid sGawEE were independently associated with diminished SGaWEE at 1 year. Conclusions--Diminished airway function at the end of the first year appears to be mediated by impaired airway development during early life as well as by exposure to maternal smoking. These findings are consistent with the hypothesis that, at a population level, diminished premorbid airway function provides the link between wheezing lower respiratory illness and diminished airway function at 1 year. Maternal smoking remains an important and avoidable cause of impaired airway development and function in infancy.


Related Articles

  • Pfeifende Atmung (...Wheezing") beim Säugling und Kleinkind: Aktuelle Standpunkte. Horak, Elisabeth // Wiener Klinische Wochenschrift;2004, Vol. 116 Issue 1/2, p15 

    Wheezing in infants and toddlers is a common symptom, and these patients are difficult to approach - both diagnostically and therapeutically. Congenital conditions causing wheezing disorders should not be missed and - not all wheezy bronchitis is or will become asthma. Results from longitudinal...

  • Does the Inclusion of Wheeze Detection as an Outcome Measure Affect the Interpretation of Methacholine Challenge Tests? A Study in Workers at Risk of Occupational Asthma. Bohadana, Abraham; Michaely, J.-P. // Lung;May/Jun2006, Vol. 184 Issue 3, p151 

    Methacholine $ \dot{\rm V} $ challenge testing (MCT) is widely used to assess airway hyperresponsiveness (AHR). Traditionally, a 20% or greater decline in forced expiratory volume in 1 (FEV1) is the primary outcome measure. We examined whether the inclusion of wheeze detection as outcome measure...

  • Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a... Strachan, David P.; Butland, Barbara K. // BMJ: British Medical Journal (International Edition);5/11/96, Vol. 312 Issue 7040, p1195 

    Presents information on a study on the incidence of asthma and prognosis of asthma and wheezing illness from early childhood to middle age among Britons. Impact of environment and lifestyle; Effect of smoking on onset of adult wheezing; Development of asthma/wheezy bronchitis in children.

  • How do we treat wheezing infants? Evidence or anecdote. Chavasse, R.J.; Bastian-Lee, Y.; Seddon, P. // Archives of Disease in Childhood;Dec2002, Vol. 87 Issue 6, p546 

    Discusses key issues concerning the management of wheeze in infancy, a condition largely ignored in the asthma guidelines despite evidence of a differing aetiology and response to treatment compared to older children. Key issues of interest; Analysis of pertinent topics and relevant issues;...

  • Managing and treating preschool wheeze. Grigg, Jonathan // Practice Nurse;6/11/2010, Vol. 39 Issue 11, p18 

    The article assesses several therapy options and areas of continued uncertainty on whether therapies designed for school-age atopic asthma are effective for pre-school wheeze. The pre-school age range for children experiencing wheeze is 1-6 years. Evidences concerning the management and...

  • The wheezing infant. Morris, David // Update;May2006, Vol. 72 Issue 5, p75 

    This article focuses on the diagnosis, treatment and referral of wheezing infants. A wheezing infant or toddler with concerned parents is a relatively frequent presentation in general practice. Up to 50% of children are estimated to wheeze in their pre-school years. The majority of wheezy...

  • Recurrent wheezing in infants: epidemiological changes. Chong Neto, Herberto José; Rosário, Nelson Augusto; Grasselli, Emanuel Antônio; e Silva, Flávia Carnieli; Fátima Melniski Bojarski, Lylia de; Rosário, Cristine Secco; Rosário, Bernardo Augusto; Chong, Fernando Henrique // Jornal de Pediatria;Nov/Dec2011, Vol. 87 Issue 6, p547 

    Objective: To determine epidemiological changes in recurrent wheezing among infants in Curitiba, Brazil. Method: This cross-sectional study used the questionnaire Estudio Internacional de Sibilancias en Lactantes (EISL). Parents of infants aged 12 to 15 months completed the instrument from...

  • Factors influencing the relation of infant feeding to asthma and recurrent wheeze in childhood. Wright, A. L.; Holberg, C. J.; Taussig, L. M.; Martinez, D.; Martinez, F D // Thorax;Mar2001, Vol. 56 Issue 3, p192 

    Background: The relationship between infant feeding and childhood asthma is controversial. This study tested the hypothesis that the relation between breast feeding and childhood asthma is altered by the presence of maternal asthma.Methods: Healthy non-selected newborn...

  • Early-life antibiotics linked to wheezing.  // Contemporary Pediatrics;Sep2008, Vol. 25 Issue 9, p36 

    The article discusses research being done on a link between wheezing in infants and their intake of antibiotics. It references a study published in the August 2008 issue of the journal "Clinical and Experimental Allergy." The study found that infants who are given antibiotics in the first three...


Read the Article


Sign out of this library

Other Topics