TITLE

Effects of inhaled salbutamol in exercising non-asthmatic athletes

AUTHOR(S)
Goubault, C.; Perault, M-C.; Leleu, E.; Bouquet, S.; Legros, P.; Vandel, B.; Denjean, A.
PUB. DATE
September 2001
SOURCE
Thorax;Sep2001, Vol. 56 Issue 9, p675
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background--Beta-2 agonists such as salbutamol are used, not only by asthmatic athletes to prevent exercise induced asthma, but also by non-asthmatic athletes as a potentially ergogenic agent. We have investigated whether inhaled salbutamol enhances endurance performance in non-asthmatic athletes. Methods--A prospective double blind, randomised, three way crossover design was used to study the effects of 200 μg and 800 μg inhaled salbutamol versus a placebo in 12 trained triathletes. The treatments were compared in three identical cycle ergometer sessions at 85% of the predetermined maximal oxygen uptake. Lung function, endurance time, metabolic parameters (glucose, potassium, lactate, free fatty acid, and glycerol), and psychomotor performance were evaluated. Results--Neither endurance time nor post-exercise bronchodilation were significantly different between the treatments. Metabolic parameters were affected by exercise but not by treatment. Conclusions--Inhaled salbutamol, even in a high dose, did not have a significant effect on endurance performance in non- asthmatic athletes, although the bronchodilating effect of the drug at the beginning of exercise may have improved respiratory adaptation. Our results do not preclude an ergogenic effect of β2 agonists given by other routes or for a longer period.
ACCESSION #
12927255

 

Related Articles

  • COMMENTARY. Ribas, J. // British Journal of Sports Medicine;Aor2006, Vol. 40 Issue 4, p366 

    The article comments on the paper "Use of β2 agonists in sport: are the present criteria right?," by J. Naranjo Orellana and colleagues in this issue. The findings show that the use of these drugs could provide the asthmatic athlete the chance of full breathing capacity without any extra...

  • Use of β2 agonists in sport: are the present criteria right? Naranjo^ Orellana, J.; Prada, R. A. Centeno; Márquez, M. D. Carranza // British Journal of Sports Medicine;Aor2006, Vol. 40 Issue 4, p363 

    Background: The regulations for doping control prohibit the use of β2 agonist bronchodilators (salbutamol, salmeterol, formoterol, and terbutaline) unless the subject follows the procedure known as abbreviated therapeutic use exemption (ATUE). Objective: To highlight how the interest in...

  • Comparison of Salbutamol and Ipratropium Spray in Treatment of COPD. Soltani, A.; Taghvace, T.; Terkami, S. F. Emadi // Journal of Mazandaran University of Medical Sciences (JMUMS);2008, Vol. 17 Issue 62, p12 

    This is a clinical trial regarding the comparative effect of two drugs in COPD patients. The drugs were Salbutamol and Ipratropoim bromide that are being used commonly in the treatment of COPD. Salbotamol is less expensive in Iran and more available than Ipratropim. We chose 16 patients which...

  • Effect of Zafirlukast on improving lung function in patients with chronic obstructive pulmonary diseases. Moosavi, Seyed Ali Javad; Raji, Hanieh; Tasorian, Baharak; Mostafapour, Elyas; Shahabi, Shahab; Purfakharan, Mohammad; Fereshtehnejad, Seyed-Mohammad // Medical Journal of the Islamic Republic of Iran;May2013, Vol. 27 Issue 2, p57 

    Background: There is little evidence about the role of Zafirlukast (a highly selective LTD4 antagonist) in Chronic Obstructive Pulmonary Disease (COPD). The Zafirlukast can reduce the need for short-acting rescue β2 agonists, produce fewer exacerbations of asthma and increased quality of life...

  • SENSITIVITY OF IMPULSE OSCILLOMETRY AND SPIROMETRY IN THE ASSESSMENT OF BETA-BLOCKER INDUCED BRONCHOCONSTRICTION AND BETA-AGONIST BRONCHODILATATION IN MILD-TO-MODERATE ASTHMATICS. Short, P. M.; Williamson, P. A.; Lipworth, B. J. // Thorax;Dec2011 Supplement, pA7 

    Introduction and Objectives Impulse oscillometry (IOS) is known to be a sensitive marker of airway dysfunction, but is commonly associated with a wider variation than spirometry. The effects of β-blocker induced bronchoconstriction on IOS have not been studied. We compared the sensitivities...

  • Salmeterol/Fluticasone Propionate in a Single Inhaler is Superior to Budesonide Alone in Control of Chinese Asthmatic Adults. Nan Shan Zhong; Zheng Jin Ping; Humphries, Michael J.; Du Xin // Clinical Drug Investigation;2004, Vol. 24 Issue 10, p583 

    Objective and design: There is comparatively little information on asthma management in China. A multicentre, randomised, open-label, parallel-group, 6-week treatment study was conducted to evaluate the efficacy and safety of salmeterol/fluticasone propionate combination treatment in Chinese...

  • Selection of confounding variables should not be based on observed associations with exposure. Groenwold, Rolf; Klungel, Olaf; Grobbee, Diederick; Hoes, Arno // European Journal of Epidemiology;Aug2011, Vol. 26 Issue 8, p589 

    In observational studies, selection of confounding variables for adjustment is often based on observed baseline incomparability. The aim of this study was to evaluate this selection strategy. We used clinical data on the effects of inhaled long-acting beta-agonist (LABA) use on the risk of...

  • Management of asthma in children. Townshend, J.; Hails, S.; Mckean, M. // BMJ: British Medical Journal (International Edition);8/4/2007, Vol. 335 Issue 7613, p253 

    The article presents an overview of the management of asthma in children. A discussion of what the acute managemnt of asthma, long term management of atopic asthma and episodic viral wheeze is is presented. The benefits and disadvantages of the use of corticosteroids and long acting beta...

  • Decreased bronchodilating effect of salbutamol in relieving methacholine induced moderate to severe bronchoconstriction during high dose treatment with long acting Î’2 agonists. van der Woude, H. J.; Winter, T. H.; Aalbers, R. // Thorax;Jul2001, Vol. 56 Issue 7, p529 

    Background-In vitro the long acting β2, agonist salmeterol can, in contrast to formoterol, behave as a partial agonist and become a partial antagonist to other β2 agonists. To study this in vivo, the bronchodilating effect of salbutamol was measured during methacholine induced moderate to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics