Systemic effects of inhaled corticosteroids are milder in asthmatic patients than in normal subjects

Fabbri, L.; Melara, R.
March 2001
Thorax;Mar2001, Vol. 56 Issue 3, p165
Academic Journal
Inhaled glucocorticosteroids are the first line anti-inflammatory agents for the long term treatment of asthma. They are also frequently prescribed in chronic obstructive pulmonary disease (COPD), even if their efficacy in this condition is still controversial. The inhalatory mode of administration maximizes the delivery to the airways and minimizes the systemic delivery of gIucocorticosteroids increasing the therapeutic ratio. However, long term treatment of asthma and COPD with inhaled corticosteroids is associated with a significant risk of dose related systemic adverse events.


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