Authors' reply

Dentener, M. A.; Creutzberg, E. C.; Wouters, E. F. M.
June 2002
Thorax;Jun2002, Vol. 57 Issue 6, p564
Academic Journal
The article describes about levels of C reactive protein (CRP) in the healthy controls and patients with clinically stable chronic obstructive pulmonary disease (COPD). The control group used consisted of randomly selected subjects over 50 years of age and living in the same area as the patients. These subjects had no evidence of COPD based on questionnaires and lung function testing, did not exhibit any acute or chronic disease, and were not taking medication. Based on these selection criteria, this group was considered a healthy population control group. Although two of the 23 control subjects had enhanced CRP levels, the reason for which is unknown, they were not excluded in order to prevent bias. Non-parametric tests were used to compare the CRP levels between controls and COPD patients, and therefore the results are not affected by these two outliers.


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