Authors' reply

Joos, I.; Pare, P. D.; Sandford, A.
June 2002
Thorax;Jun2002, Vol. 57 Issue 6, p562
Academic Journal
Researchers J. Karajalainen and colleagues present interesting data on the relationship of IL-1β and IL-1 receptor antagonist haplotypes and the rate of decline of lung function in incident asthmatic subjects in a Finnish cohort. Researchers reported that the IL1RN AI/IL1B-5l1T haplotype was associated with a more rapid decline in lung function in smokers in the Lung Health Study; in contrast, they found that this same haplotype was associated with a slower rate of decline in lung function in patients with asthma. Authors suggest that this apparent contradiction may be because the function of these haplotypes is disease specific.


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