Spread of an epidemic Pseudomonas aeruginosa strain from a patient with cystic fibrosis (CF) to non-CF relatives

McCallum, S. J.; Gallagher, M. J.; Corkill, J. E.; Hart, C. A.; Ledson, M. J.; Walshaw, M. J.
June 2002
Thorax;Jun2002, Vol. 57 Issue 6, p559
Academic Journal
Colonisation with Pseudomonas aeruginosa is common in adults with cystic fibrosis (CF) and there is increasing evidence that transmissible strains may cross colonise patients. However, transmission of these strains by social contact to healthy non-CF individuals has not been described. A case is presented where an adult CF patient colonised by an epidemic P aeruginosa strain infected her parent with subsequent morbidity.


Related Articles

  • The spectrum of cystic fibrosis exacerbations.  // Thorax;Dec2006 Supplement 2, Vol. 61, pii33 

    The article presents abstracts of medical research related to the spectrum of cystic fibrosis exacerbations. They include "Characterization of Bacterial Diversity in Cystic Fibrosis Sputum," "Outcome of Burkholderia Cepacia Complex Pulmonary Infection in Patients with Cystic Fibrosis from...

  • Mucoid Pseudomonas aeruginosa and Cystic Fibrosis.  // Clinical Infectious Diseases;6/15/2005, Vol. 40 Issue 12, preceding p1 

    The article focuses on mucoid Pseudomonas aeruginosa and cystic fibrosis. The natural history of the acquisition of mucoid and nonmucoid strains of Pseudomonas aeruginosa in patients with cystic fibrosis was prospectively evaluated in 56 patients observed from birth to the age of 16 years. The...

  • Mucoidy, Quorum Sensing, Mismatch Repair and Antibiotic Resistance in Pseudomonas aeruginosa from Cystic Fibrosis Chronic Airways Infections. Feliziani, Sofía; Luján, Adela M.; Moyano, Alejandro J.; Sola, Claudia; Bocco, José L.; Montanaro, Patricia; Canigia, Liliana Fernández; Argaraña, Carlos E.; Smania, Andrea M. // PLoS ONE;2010, Vol. 5 Issue 9, p1 

    Survival of Pseudomonas aeruginosa in cystic fibrosis (CF) chronic infections is based on a genetic adaptation process consisting of mutations in specific genes, which can produce advantageous phenotypic switches and ensure its persistence in the lung. Among these, mutations inactivating the...

  • Emergence of Carbapenem Resistance in Pseudomonas aeruginosa Isolates from a Patient with Cystic Fibrosis in the Absence of Carbapenem Therapy. Wolter, Daniel J.; Acquazzino, Dee; Goering, Richard V.; Sammut, Paul; Khalaf, Noha; Hanson, Nancy D. // Clinical Infectious Diseases;6/15/2008, Vol. 46 Issue 12, pe137 

    The emergence of carbapenem-resistant Pseudomonas aeruginosa in the lung of a patient with cystic fibrosis was evaluated. A single strain of P. aeruginosa persisted during a 3-year study despite antipseudomonal treatment. A stepwise decrease in carbapenem susceptibility leading to resistance was...

  • Proposal of a quantitative PCR-based protocol for an optimal Pseudomonas aeruginosa detection in patients with cystic fibrosis. Le Gall, Florence; Le Berre, Rozenn; Rosec, Sylvain; Hardy, Jeanne; Gouriou, Stéphanie; Boisramé-Gastrin, Sylvie; Vallet, Sophie; Rault, Gilles; Payan, Christopher; Héry-Arnaud, Geneviève // BMC Microbiology;2013, Vol. 13 Issue 1, p1 

    Background: The lung of patients with cystic fibrosis (CF) is particularly sensitive to Pseudomonas aeruginosa. This bacterium plays an important role in the poor outcome of CF patients. During the disease progress, first acquisition of P. aeruginosa is the key-step in the management of CF...

  • Pseudomonas aeruginosa vesicles associate with and are internalized by human lung epithelial cells. Bauman, Susanne J.; Kuehn, Meta J. // BMC Microbiology;2009, Vol. 9, Special section p1 

    Background: Pseudomonas aeruginosa is the major pathogen associated with chronic and ultimately fatal lung infections in patients with cystic fibrosis (CF). To investigate how P. aeruginosaderived vesicles may contribute to lung disease, we explored their ability to associate with human lung...

  • Expression of PPARc and Paraoxonase 2 Correlated with Pseudomonas aeruginosa Infection in Cystic Fibrosis. Griffin, Phoebe E.; Roddam, Louise F.; Belessis, Yvonne C.; Strachan, Roxanne; Beggs, Sean; Jaffe, Adam; Cooley, Margaret A. // PLoS ONE;Jul2012, Vol. 7 Issue 7, p1 

    The Pseudomonas aeruginosa quorum sensing signal molecule N-3-oxododecanoyl-L-homoserine lactone (3OC12HSL) can inhibit function of the mammalian anti-inflammatory transcription factor peroxisome proliferator activated receptor (PPAR)c, and can be degraded by human paraoxonase (PON)2. Because...

  • The Pseudomonas aeruginosa Reference Strain PA14 Displays Increased Virulence Due to a Mutation in ladS. Mikkelsen, Helga; McMullan, Rachel; Filloux, Alain // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    Pseudomonas aeruginosa is a pathogen that causes acute and chronic infections in a variety of hosts. The pathogenic potential of P. aeruginosa is strain-dependent. PA14 is a highly virulent strain that causes disease in a wide range of organisms, whereas PAO1 is moderately virulent. Although...

  • Cystic fibrosis: addressing the transition from pediatric to adult-oriented health care. Kreindler, James L.; Miller, Victoria A. // Patient Preference & Adherence;2013, Vol. 7, p1221 

    Survival for patients with cystic fibrosis (CF) increased to nearly 40 years in 2012 from the early childhood years in the 1940s. Therefore, patients are living long enough to require transition from pediatric CF centers to adult CF centers. The goal of transition is for the young adult to be...


Read the Article


Sign out of this library

Other Topics