Tissue and cell imaging in situ: potential for applications in pathology and endoscopy

Scoazec, J.-Y.
June 2003
Gut;Jun2003 Supplement 4, Vol. 52, piv1
Academic Journal
Morphological sciences have recently experienced a significant technological breakthrough that offers new opportunities for cell and tissue imaging in situ but also raises new challenges to pathologists, who must adapt to a rapidly evolving environment. New partners, such as cell and molecular biologists, have provided pathologists with highly powerful tools for cell and subcellular imaging. They include: (a) the adaptation of techniques derived from molecular biology and cytogenetics, (b) the development of new microscopic tools, such as confocal microscopy, and (c) the emergence of new preparative techniques, such as microdissection or tissue arrays. However, recent technological progresses in various fields, from endoscopy to genomics, also raise new challenges to pathologists. Pathologists must therefore be prepared to redefine their area of expertise: this will be achieved through a continuous collaboration with all the partners involved in cell and tissue imaging and analysis but also by emphasising the importance of the informations provided by cell and tissue imaging in situ.


Related Articles

  • Biological uncertainty. Zbilut, Joseph P.; Giuliani, Alessandro // Theory in Biosciences;Aug2008, Vol. 127 Issue 3, p223 

    Heisenberg's uncertainty relation has inspired speculations in a variety of scientific fields. Most of these speculations have wandered significantly far from the original formulation; yet, they may have been useful for a critical examination of methodological issues. As molecular genetics and...

  • Next-generation sequencing: The future of molecular genetics in poultry production and food safety. Diaz-Sanchez, S.; Hanning, I.; Pendleton, Sean; D'Souza, Doris // Poultry Science;Feb2013, Vol. 92 Issue 2, p562 

    The era of molecular biology and automation of the Sanger chain-terminator sequencing method has led to discovery and advances in diagnostics and biotechnology. The Sanger methodology dominated research for over 2 decades, leading to significant accomplishments and technological improvements in...

  • Recent advances in the molecular pathology, cell biology and genetics of ciliopathies. Adams, M.; Smith, U. M.; Logan, C. V.; Johnson, C. A. // Journal of Medical Genetics;May2008, Vol. 45 Issue 5, p257 

    Primary cilia have a broad tissue distribution and are present on most cell types in the human body. Until recently, they were considered to be redundant organelles, but progress over the past 5 years has led to an understanding of their role in normal mammalian development. The class of...

  • Paradigms of pathogenesis: targeting the mobile genetic elements of disease. Keen, Eric C. // Frontiers in Cellular & Infection Microbiology;Dec2012, Vol. 2 Issue 12, p1 

    The article reports on targeting the mobile genetic elements of disease.

  • 706. Withdrawn.  // Molecular Therapy;Jun2006, Vol. 13, pS273 

    Molecular Therapy (2006) 13, S273–S273; doi: 10.1016/j.ymthe.2006.08.785

  • Towards the synthetic dragonfly. Ball, Philip // Nature;5/11/1995, Vol. 375 Issue 6527, p101 

    Discusses the principles of molecular recognition and self-assembly through non-covalent interactions. Covalent network; Systems level identity of chemistry; Thin-film technology; Use of cell machinery; Blurring of the line between the living and the artificial.

  • Molecular biology in practice: The future is now. Bauman, Norman // Urology Times;July97, Vol. 25 Issue 7, p36 

    Reports on the possible changes in the field of urology through the clinical practice of molecular biology. Use of molecular engineering to produce therapeutic agents; Use of polymerase chain reaction technology to detect residual disease; Identification and characterization of tumor suppressor...

  • Tetracycline Operator/Repressor System to Visualize Fluorescence-Tagged T-DNAs in Interphase Nuclei of Arabidopsis. Matzke, Antonius J. M.; van der Winden, Johannes; Matzke, Marjori // Plant Molecular Biology Reporter;Mar2003, Vol. 21 Issue 1, p9 

    Presents information on a study that described vectors and conditions for using the tetracycline operator/repressor system and enhanced yellow fluorescent protein to visualize transgene loci in interphase nuclei of living Arabidopsis cells. Materials and methods; Results; Discussion.

  • Transient Assay for In Vivo Splicing in Tobacco Leaf Cells by Particle Bombardment. Mitsui, Michiko; Murohashi, Yoshiko; Asano, Yoshito; Masada, Masahiro; Kodama, Hiroaki // Plant Molecular Biology Reporter;Mar2003, Vol. 21 Issue 1, p21 

    Presents information on a study that provided a method for detecting spliced products from transiently expressed genes using an intron construct containing the target intron and neighboring short exons. Materials and methods; Results; Discussion.


Read the Article


Sign out of this library

Other Topics