TITLE

INHALED STEROIDS FOR COPD?

AUTHOR(S)
Tattersfield, A. E.; Harrison, T. W.
PUB. DATE
September 2001
SOURCE
Thorax;Sep2001 Supp, Vol. 56, pii2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To determine the effect of long term inhaled corticosteroids on lung function, exacerbations, and health status in patients with moderate to severe chronic obstructive pulmonary disease. Design: Double blind, placebo controlled study Setting: Eighteen UK hospitals. Participants: 751 men and women aged between 40 and 75 years with mean forced expiratory volume in one second (FEV1) 50% of predicted normal. Interventions: Inhaled fluticasone propionate 500 μg twice daily from a metered dose inhaler or identical placebo. Main outcome measures: Efficacy measures: rate of decline in FEV1 after the bronchodilator and in health status, frequency of exacerbations, respiratory withdrawals. Safety measures: morning serum cortisol concentration, incidence of adverse events. Results: There was no significant difference in the annual rate of decline in FEV1 (p=0.16). Mean FEV1 after bronchodilator remained significantly higher throughout the study with fluticasone propionate compared with placebo (p=0. 001). Median exacerbation rate was reduced by 25% from 1.32 a year on placebo to 0.99 a year with fluticasone propionate (p=0.026). Health status deteriorated by 3.2 units a year on placebo and 2.0 units a year on fluticasone propionate (p=0.0043). Withdrawals because of respiratory disease not related to malignancy were higher in the placebo group (25% v 19%, p=0.034). Conclusions: Fluticasone propionate 500 μg twice daily did not affect the rate of decline in FEV1 but did produce a small increase in FEV1. Patients on fluticasone propionate had fewer exacerbations and a slower decline in health status. These improvements in clinical outcomes support the use of this treatment in patients with moderate to severe chronic obstructive pulmonary disease.
ACCESSION #
12915388

 

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