TITLE

Effect of pulmonary rehabilitation on exhaled nitric oxide in patients with chronic obstructive pulmonary disease

AUTHOR(S)
Clini, E.; Bianchi, L.; Foglio, K.; Porta, R.; Vitacca, M.; Ambrosino, N.
PUB. DATE
July 2001
SOURCE
Thorax;Jul2001, Vol. 56 Issue 7, p519
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background-In patients with mild to moderate chronic obstructive pulmonary disease (COPD) the exercise induced increase in exhaled nitric oxide (eNO) parallels that observed in normal un-trained subjects. There is no information on the effects of the level of exercise tolerance on eNO in these patients. The aim of this study was to evaluate the effect of a pulmonary rehabilitation programme including exercise training on eNO in patients with COPD. Methods-In 14 consecutive male patients with stable COPD of mean (SD) age 64 (9) years and forced expiratory volume in one second (FEV1) 55 (14)% predicted, fractional eNO concentration (FeNo), peak work rate (Wpeak) and oxygen uptake (Vo2peak) were assessed at baseline (T-1), at the end of a 1 month run in period (T0), and after an 8 week outpatient multidisciplinary pulmonary rehabilitation programme (T1) including cycloergometer training. Results-FeNO did not significantly differ at T-1 and T0 (mean (SE) 4.3 (0.6) and 4.4 (0.6) ppb, respectively), whereas it rose significantly at T1 to 6.4 (0.7) ppb (p<0.02). Compared with T0, both Wpeak and Vo2, were significantly (p<0.05) increased at T1 (mean (SE) Wpeak from 89 (5.6) W to 109 (6.9) W); Vo2peak from 1.27 (0.1) 1/min to 1.48 (0.1) 1/min). A significant correlation was found between base- line FEV1 and the change in FeNO following the rehabilitation programme (r=0.71;p<0.05) and between changes in FeNO and Wpeak from T0 to T1(r=0.60; p<0.05). Conclusions-Pulmonary rehabilitation in patients with mild to moderate COPD is associated with an increase in exhaled nitric oxide.
ACCESSION #
12915351

 

Related Articles

  • Review: Nedocromil sodium decreases airflow reduction and recovery time in exercise-induced bronchoconstriction. Grosser, Dion; Smith, Brian // ACP Journal Club;Sep/Oct2002, Vol. 137 Issue 2, p71 

    Presents a study that investigated the effect of nedocromil sodium in reducing the severity and duration of symptoms in patients with exercise-induced bronchoconstriction. Information on data sources and study selection; Comparison of outcomes in nedocromil sodium versus placebo; Assessment of...

  • The Role of Breathing Exercises in the Treatment of COPD. YANCEY, JOSEPH R.; CHAFFEE, DONALD // American Family Physician;1/1/2014, Vol. 89 Issue 1, p15 

    The article provides an evidence-based answer to a question of whether breathing exercises can led to improvements in dyspnea, exercise capacity and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD).

  • Winter weather and COPD. Riley, Jo // Independent Nurse;1/18/2010, p17 

    The article discusses cases of chronic obstructive pulmonary disease (COPD) during the winter season in Great Britain. It cites that the cold weather and winter infections can exacerbate cases of COPD. It also claims that COPD is the fifth major cause of death in the country, causing 82 deaths...

  • Non-invasive evaluation of gas exchange during a shuttle walking test vs. a 6-min walking test to assess exercise tolerance in COPD patients. Onorati, Paolo; Antonucci, Rosa; Valli, Gabriele; Berton, Emanuela; De Marco, Francesca; Serra, Pietro; Palange, Paolo // European Journal of Applied Physiology;May2003, Vol. 89 Issue 3/4, p331 

    Walking tests, such as the "shuttle" incremental walking test (SWT) and the 6-min walking test (6'WT), are commonly utilized in evaluating exercise intolerance in patients with chronic obstructive pulmonary disease (COPD) and the distance covered is the variable usually considered. Because lung...

  • Breath-by-breath fluctuations of pulmonary gas exchange and ventilation in COPD patients. Puente-Maestu, Luis; Ma JesúsAbad; Godoy, Raul; Pérez-Parra, José Ma; Cubillo, Josú M.; Whipp, Brian J. // European Journal of Applied Physiology;Oct2002, Vol. 87 Issue 6, p535 

    The purpose of the study was to characterise statistically the inherent fluctuations in breath-by-breath measurements of pulmonary gas exchange (oxygen uptake and carbon dioxide output, VO2 and VCO2, respectively) and pulmonary ventilation (VE) in patients with chronic obstructive pulmonary...

  • Commentary. Rees, P. John // Evidence Based Medicine;Feb2006, Vol. 11 Issue 1, p20 

    The article comments on a study by A. D. Smith and colleagues to determine whether optimizing the inhaled corticosteroid dose using the fraction of nitric oxide in exhaled air can reduce asthma exacerbations and the daily dosage compared to the use of standard criteria for patients with chronic...

  • Diagnosing Asthma in Young Children.  // AARC Times;Apr2009, Vol. 33 Issue 4, p8 

    The article offers information on diagnosing asthma in young children. The article defines asthma as a chronic inflammatory disease characterized by airway hyperreactivity and acute episodes of airflow obstruction from bronchoconstriction. Experts cited three general criteria for the diagnosis...

  • L-Arginine Supplementation and Metabolism in Asthma. Kenyon, Nicholas J.; Last, Michael; Bratt, Jennifer M.; Kwan, Vivian W.; O'Roark, Erin; Linderholm, Angela // Pharmaceuticals;Jan2011, Vol. 4 Issue 1, p187 

    L-Arginine, the amino acid substrate for nitric oxide synthase, has been tested as a therapeutic intervention in a variety of chronic diseases and is commonly used as a nutritional supplement. In this study, we hypothesized that a subset of moderate to severe persistent asthma patients would...

  • Using exhaled NO concentrations to adjust inhaled corticosteroid dose maintained asthma control and reduced the dose. Smith, A. D.; Cowan, J. O.; Brassett, K. P.; Taylor, R. // Evidence Based Medicine;Feb2006, Vol. 11 Issue 1, p20 

    The article reports on a study to determine whether optimizing the inhaled corticosteroid dose using the fraction of nitric oxide in exhaled air can reduce asthma exacerbations and the daily dosage compared to the use of standard criteria for patients with chronic asthma. Patients aged 12-75...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics