Revisiting interactions between hypoxaemia and β2 agonists in asthma

Lipworth, B. J.
July 2001
Thorax;Jul2001, Vol. 56 Issue 7, p506
Academic Journal
The excessive use of β² agonists has been associated with increased asthma mortality, although this seems to be due to confounding by disease severity rather than direct drug toxicity. Dose-response studies in stable asthmatics have shown the potential for high doses of salbutamol to produce direct or indirect cardiovascular sequelae mediated by extrapulmonary β² adrenoceptor stimulation including chronotropic and inotropic activity, peripheral vasodilatation, electrocardiographic changes, as well as hypokalaemia and hypomagnesaemia.


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