Animal models of chronic obstructive pulmonary disease

Dawkins, P. A.; Stockley, R. A.
December 2001
Thorax;Dec2001, Vol. 56 Issue 12, p972
Academic Journal
Chronic obstructive pulmonary disease (COPD) is the fifth leading cause of death in Great Britain, causing 26, 000 deaths and 240,000 hospital admissions and costing the $486 million per annum. It is also a global problem, reaching almost epidemic proportions in the developing world. Despite this, it receives relatively little attention compared with diseases with a similar impact such as coronary heart disease and cancer. Animal models act as a bridge between in vitro studies in the laboratory and studies in humans. In COPD, in particular, animal models would enable basic research to investigate the mechanisms of inflammatory cell recruitment and abnormal matrix repair and alternative hypotheses of the pathogenesis of emphysema such as those implicating lung cell apoptosis as a primary event.


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