TITLE

Ultrafine particles in alveolar rnacrophages from normal children

AUTHOR(S)
Bunn, H. J.; Dinsdale, D.; Smith, T.; Grigg, J.
PUB. DATE
December 2001
SOURCE
Thorax;Dec2001, Vol. 56 Issue 12, p932
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background-Increased ambient levels of it particulate matter <10 μm (PM10) from ir fossil fuel combustion are associated with an increased prevalence of respiratory symptoms in children. However, it is unknown whether, and to what extent, pollutant particles penetrate the paediatric lower airway. The capacity of alveolar macrophages (AM) to phagocytose inhaled material was used to directly assess exposure of normal children to particles. Methods-AM from 22 children aged 3 months to 16 years with no respiratory symptoms were obtained by non- bronchoscopic bronchoalveolar lavage prior to elective surgery. In each child the size and composition of environmental I particles within single sections from 100 separate AM was determined by electron microscopy and microanalysis. Results-Single and clusters of particles were seen in AM from all children. The percentage of particle-containing AM ranged from 1% to 16% per child. Particles consisted of a carbonaceous core and all were ultrafine (<0.1 pm). Other elements such as metals and silicon were not detected. The percentage of particle containing AM did not change with age, but was increased in children whose parents lived on a main road compared with those living on a quiet residential road (median 10% v 3%, p = 0.014). Conclusions-All children had AM containing ultrafine carbonaceous particles. The predominant source of these particles is most likely to be from the combustion of fossil fuels.
ACCESSION #
12915290

 

Related Articles

  • The Role of Exercise in Evaluating and Managing Pulmonary Disorders in Children and Adolescents. Boas, Steven R.; Nevin, Mary A. // International SportMed Journal;2001, Vol. 2 Issue 5, p1 

    Exercise testing, as a diagnostic and therapeutic modality in managing pulmonary diseases in children, has not been fully utilized, Monitoring the unique response to the stress of exercise that children possess can aid in the diagnosis of pulmonary pathophysiology, This review addresses the...

  • Pulmonary infections. Daltro, Pedro; Santos, Eloá N.; Gasparetto, Taísa D.; Ucar, Maria E.; Marchiori, Edson // Pediatric Radiology;May2011, Vol. 41, p69 

    This paper reviews the most common imaging findings of pulmonary infection in children. Pneumonia is a leading cause of mortality in children in developing and industrialized countries. While the imaging findings usually are nonspecific, correlation with the patient's age, immune status and...

  • Pulmonary Langerhans cell histiocytosis. Kose, Mehmet; Ozdemir, Mehmet // European Journal of Pediatrics;Sep2013, Vol. 172 Issue 9, p1283 

    Herein, we described 16-year-old boy with pulmonary cysts in both lung fields and diagnosed as isolated pulmonary Langerhans cell histiocytosis.

  • The fetal MR appearance of 'nutmeg lung': findings in 8 cases linked to pulmonary lymphangiectasia. Victoria, Teresa; Andronikou, Savvas // Pediatric Radiology;Oct2014, Vol. 44 Issue 10, p1237 

    Background: A pattern of abnormal signal at fetal MRI may be seen in the setting of primary or secondary congenital lymphangiectasia, manifested as a heterogeneous appearance of the lung parenchyma and the presence of subtle T2-hyperintense branching tubular structures that emanate from the...

  • Lung ultrasound in bronchiolitis: comparison with chest X-ray. Caiulo, Vito; Gargani, Luna; Caiulo, Silvana; Fisicaro, Andrea; Moramarco, Fulvio; Latini, Giuseppe; Picano, Eugenio; Caiulo, Vito Antonio // European Journal of Pediatrics;Nov2011, Vol. 170 Issue 11, p1427 

    The diagnosis of bronchiolitis is based mainly on the patient's medical history and physical examination. However, in severe cases, a further evaluation including chest X-ray (CXR) may be necessary. At present, lung ultrasound (LUS) is not included in the diagnostic work-up of bronchiolitis....

  • Biodegradability of Para-aramid Respirable-Sized Fiber-Shaped Particulates (RFP) in Human Lung Cells1 The authors ceritify that all research involving human subjects was done under full compliance with all government policies and the Helsinki Declaration. Warheit, D. B.; Reed, K. L.; Stonehuerner, J. D.; Ghio, A. J.; Webb, T. R. // Toxicological Sciences;Jan2006, Vol. 89 Issue 1, p296 

    Using both in vivo (inhalation) and in vitro (cell culture) studies, we previously reported that p-aramid respirable fibers (RFP—defined as respirable-sized fiber-shaped particulates) are biodegraded in lungs and lung cells of rats following exposures. The current studies were undertaken...

  • Intracellular fate of carbon nanotubes inside murine macrophages: pH-dependent detachment of iron catalyst nanoparticles. Bussy, Cyrill; Paineau, Erwan; Cambedouzou, Julien; Brun, Nathalie; Mory, Claudie; Fayard, Barbara; Salomé, Murielle; Pinault, Mathieu; Huard, Mickaël; Belade, Esther; Armand, Lucie; Boczkowski, Jorge; Launois, Pascale; Lanone, Sophie // Particle & Fibre Toxicology;2013, Vol. 10 Issue 1, p1 

    Background: Carbon nanotubes (CNT) are a family of materials featuring a large range of length, diameter, numbers of walls and, quite often metallic impurities coming from the catalyst used for their synthesis. They exhibit unique physical properties, which have already led to an extensive...

  • Morphology and ultrastructure of blood cells of the tammar wallaby Macropus eugenii. Young, L. J.; Deane, E. M. // Comparative Clinical Pathology;Aug2005, Vol. 14 Issue 1, p36 

    The morphology of the peripheral blood leukocytes of the tammar wallaby, Macropus eugenii, was investigated using both light and electron microscopy. In a study of 44 captive tammar wallabies, the five main families of mammalian leukocytes were identified and found to be similar to those of...

  • Fucosidosis with angiokeratoma. Light and electron microscopic study of a new case. Kanitakis, J.; Deroo-Berger, M. C.; Grande, S.; Blanc, S.; Claudy, A. // Journal of Investigative Dermatology;Nov2004, Vol. 123 Issue 5, pA87 

    Fucosidosis (MIM# 230000) is a rare autosomal recessive lysosomal storage disease due to deficiency of the enzyme fucosidase, resulting in tissue accumulation of fucosylated glycoconjugates. It manifests with progressive mental and motor deterioration, coarse facies, growth retardation,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics