TITLE

Non-steroidal anti-inflammatory drugs decrease the quality of pleurodesis after mechanical pleural abrasion

AUTHOR(S)
Lardinois, D.; Vogt, P.; Yang, L.; Hegyi, I.; Baslam, M.; Weder, W.
PUB. DATE
May 2004
SOURCE
European Journal of Cardio-Thoracic Surgery;May2004, Vol. 25 Issue 5, p865
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Non-steroidal anti-inflammatory drugs (NSAIDs) are often applied for pain management after thoracic surgery. Since these drugs diminish collagen deposition through inhibition of the prostaglandin synthesis, we investigated their effects on adhesion formation after endoscopic mechanical pleural abrasion, which is often applied in the therapy of pneumothorax. Methods: Mechanical pleural abrasion was performed unilaterally by the use of video-assisted thoracoscopic surgery technique in an established pig model. Ten animals (41.3±3.4 kg) were divided into a treatment group and a control group. In the treatment group, animals received 100 mg diclofenac (2 mg/kg body weight) orally daily for 3 weeks after surgery. At 3 weeks, all animals were sacrificed and efficacy of pleurodesis was macroscopically assessed by three independent reviewers blinded to the treatment of animals using a five-point severity pleurodesis score (from 0, no adhesions to 4, complete symphisis) and obliteration grade rating the distribution of adhesions (from 0, no adhesions to 4, adhesions in the whole chest). Microscopic evaluation was performed by two pathologists blinded to the study groups as well. A four-point score assessed the amount of collagen deposition (from 1, a few collagen fibers to 4, scar). Results: Gross observation showed more dense adhesions in control animals with a median pleurodesis score of 3.67±1.0 in comparison to 2±2.2 in the treatment group (P=0.01*, Mann–Whitney non-parametric test). Distribution of adhesions was comparable in both groups with a median obliteration score of 3.67±1.3. Histopathologic examination showed a higher amount of collagen deposition in the control group, suggesting more dense adhesions, whereas in the treatment group there was loose granulation tissue (score of 4.0±0.8 vs. 2.3±1.0 in the treatment group, P=0.06). The degree of inflammatory reaction was comparable in the two groups. Conclusions: Our results demonstrate that perioperative use of NSAIDs highly affects the quality of pleural adhesions obtained after mechanical abrasion in this pig model, which further suggests that these drugs should be avoided for pain management when a pleurodesis is performed.
ACCESSION #
12779366

 

Related Articles

  • local hormone (Major drug group).  // Royal Society of Medicine: Medicines;2002, p337 

    The article presents information on the local hormone. Local hormones are mediators of body signals. One of their best functions is their role in inflammation. They mediate responses in the body that are pro-inflammatory, such as histamine and members of the prostaglandin family. There are many...

  • Intracavernosal prostaglandin E1 self vs office injection therapy in patients with erectile dysfunction. El-Sakka, A. I. // International Journal of Impotence Research;Mar/Apr2006, Vol. 18 Issue 2, p180 

    We have investigated the reliability of intracavernosal prostaglandin E1 (PGE1) office vs self-injection therapy in patients with erectile dysfunction (ED). A total of 298 male patients with ED were enrolled in this study. In all patients, intracavernosal titration of the PGE1 dose was...

  • Meeting Challenges in Asymmetric Synthesis. Van Arnum, Patricia // Pharmaceutical Technology;Sep2012, Vol. 36 Issue 9, p48 

    The article reports that chiral technology is important in pharmaceutical synthesis as industry and academia advance novel approaches for achieving enantioselectivity. Due to prostaglandins' biological activity, but difficulty in synthesizing them, strategies for better synthetic routes for...

  • prostaglandin drugs. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p631 

    An encyclopedia entry for "prostaglandin drugs" is presented. They refer to synthetically produced prostaglandins. Dinoprostone and Mifepristone are examples of prostaglandin drugs. Dinoprostone is used with synthetic oxytocin to induce labor.

  • Rofecoxib for colorectal adenomas increased thrombotic events: Commentary. Juurlink, David // Evidence Based Medicine;Aug2005, Vol. 10 Issue 4, p106 

    Presents information on the interaction of drugs that inhibit cyclooxygenase 2 (COX 2) on the synthesis of prostaglandins. Functions of COX 2; Role of COX 2 inhibitors in increasing the risk of cardiovascular (CV) events; Relationship between rofecoxib and CV events.

  • ANTIGLAUCOMA, PROSTAGLANDINS. GRIFFITH, H. WINTER // Complete Guide to Prescription & Nonprescription Drugs 2012;2009, p104 

    The article presents information on prostaglandins, an antiglaucoma class of drug, including dosage, usage, adverse reactions, side effects, precautions, and possible interaction with other drugs.

  • The Impact of Ocular Adverse Effects in Patients Treated With Topical Prostaglandin Analogs: Changes in Prescription Patterns and Patient Persistence. Zimmerman, Thom J.; Hahn, Steven R.; Gelb, Laurie; Tan, Hiangkiat; Kim, Elizabeth E. // Journal of Ocular Pharmacology & Therapeutics;Apr2009, Vol. 25 Issue 2, p145 

    Purpose: To document patient/physician perceptions of adverse effects and their relationship to medication changes among patients prescribed prostaglandin analogs. Methods: Medical/pharmacy claims (private U.S. health network) identified patients filling initial topical ocular hypotensive...

  • Prostaglandins: Newest of the Hormones? Patel, Natoo // Annals of Internal Medicine;Sep70, Vol. 73 Issue 3, p483 

    Editorial. Offers observation on prostaglandins. Historical background on the word prostaglandin; Description on isotopically labeled prostaglandins; Relationship between the concentration of total prostaglandins in human seminal fluid and the degree of fertility.

  • Study: Three glaucoma agents were well tolerated.  // Primary Care Optometry News;Apr2013, Vol. 18 Issue 4, p1 

    The article reports on a study on the ocular surface tolerability of prostaglandin analogs.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics