TITLE

PERSPECTIVES IN BASIC SCIENCE Mechanism of steroid action in renal epithelial cells

AUTHOR(S)
De Haij, Simon; Daha, Mohamed R.; Van Kooten, Cees
PUB. DATE
May 2004
SOURCE
Kidney International;May2004, Vol. 65 Issue 5, p1577
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mechanism of steroid action in renal epithelial cells. Renal tubular epithelial cells (TEC) are thought to play an active role in tubulointerstitial inflammation. Various immune and non-immune factors activate TEC to produce a variety of cytokines and chemokines, contributing to attraction of inflammatory cells to the kidney. The proinflammatory transcription factor nuclear factor-κB (NF-κB) appears to be a key player in these responses and tubular expression of NF-κB has been demonstrated in vitro and in vivo. Although glucocorticoids are known to inhibit NF-κB activation at different levels, the proinflammatory capacity of TEC was not inhibited. In contrast, glucocorticoids seemed to enhance the profibrotic response of TEC, emphasizing the cell-type specific characteristics of glucocorticoid action. We propose that specific inhibition of NF-κB activation in TEC might be an attractive strategy for therapeutic intervention in renal inflammation.
ACCESSION #
12767125

 

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