TITLE

Avian Influenza: A New Pandemic Threat?

AUTHOR(S)
Trampuz, Andrej; Prabhu, Rajesh M.; Smith, Thomas F.; Baddour, Larry M.
PUB. DATE
April 2004
SOURCE
Mayo Clinic Proceedings;Apr2004, Vol. 79 Issue 4, p523
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
In December 2003, the largest outbreak of highly pathogenic avian influenza H5N1 occurred among poultry in 8 Asian countries. A limited number of human H5N1 infections have been reported from Vietnam and Thailand, with a mortality rate approaching 70%. Deaths have occurred in otherwise healthy young individuals, which is reminiscent of the 1918 Spanish influenza pandemic. The main presenting features were fever, pneumonitis, lymphopenia, and diarrhea. Notably, sore throat, conjunctivitis, and coryza were absent. The H5N1 strains are resistant to amantadine and rimantadine but are susceptible to neuraminidase inhibitors, which can be used for treatment and prophylaxis. The widespread epidemic of avian influenza in domestic birds increases the likelihood for mutational events and genetic reassortment. The threat of a future pandemic from avian influenza is real. Adequate surveillance, development of vaccines, outbreak preparedness, and pandemic influenza planning are important. This article summarizes the current knowledge on avian influenza, including the virology, epidemiology, diagnosis, and management of this emerging disease.
ACCESSION #
12736785

 

Related Articles

  • Potential Impact of Antiviral Drug Use during Influenza Pandemic. Gani, Raymond; Hughes, Helen; Fleming, Douglas; Griffin, Thomas; Medlock, Jolyon; Leach, Steve // Emerging Infectious Diseases;Sep2005, Vol. 11 Issue 9, p1355 

    The recent spread of highly pathogenic strains of avian influenza has highlighted the threat posed by pandemic influenza. In the early phases of a pandemic, the only treatment available would be neuraminidase inhibitors, which many countries are considering stockpiling for pandemic use. We...

  • Functional significance of the hemadsorption activity of influenza virus neuraminidase and its alteration in pandemic viruses. Uhlendorff, Jennifer; Matrosovich, Tatyana; Klenk, Hans-Dieter; Matrosovich, Mikhail // Archives of Virology;Jun2009, Vol. 154 Issue 6, p945 

    Human influenza viruses derive their genes from avian viruses. The neuraminidase (NA) of the avian viruses has, in addition to the catalytic site, a separate sialic acid binding site (hemadsorption site) that is not present in human viruses. The biological significance of the NA hemadsorption...

  • Identification of critical residues of influenza neuraminidase in viral particle release. Tisoncik, Jennifer R.; Ying Guo; Cordero, Katie S.; Jia Yu; Jianwei Wang; Youjia Cao; Lijun Rong // Virology Journal;2011, Vol. 8 Issue 1, p14 

    Background: Influenza neuraminidase (NA) is essential for virus release from its host cells and it is one of the targets for structure-based antiviral drug design. Results: In this report, we established a pseudoviral particle release assay to study NA function, which is based on lentiviral...

  • Cross-Reactive Neuraminidase Antibodies Afford Partial Protection against H5N1 in Mice and Are Present in Unexposed Humans. Sandbulte, Matthew R.; Jimenez, Gretchen S.; Boon, Adrianus C. M.; Smith, Larry R.; Treanor, John J.; Webby, Richard J. // PLoS Medicine;Feb2007, Vol. 4 Issue 2, p265 

    Background A pandemic H5N1 influenza outbreak would be facilitated by an absence of immunity to the avian-derived virus in the human population. Although this condition is likely in regard to hemagglutinin-mediated immunity, the neuraminidase (NA) of H5N1 viruses (avN1) and of endemic human H1N1...

  • Characterization of Neuraminidases from the Highly Pathogenic Avian H5N1 and 2009 Pandemic H1N1 Influenza A Viruses. Jia Wu; Fengwei Zhang; Maorong Wang; Chunqiong Xu; Jingdong Song; Jianfang Zhou; Xiaojing Lin; Yonghui Zhang; Xiaobing Wu; Wenjie Tan; Jian Lu; Honglan Zhao; Jimin Gao; Ping Zhao; Jianxin Lu; Yue Wang // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    To study the precise role of the neuraminidase (NA), and its stalk region in particular, in the assembly, release, and entry of influenza virus, we deleted the 20-aa stalk segment from 2009 pandemic H1N1 NA (09N1) and inserted this segment, now designated 09s60, into the stalk region of a highly...

  • Complete-Proteome Mapping of Human Influenza A Adaptive Mutations: Implications for Human Transmissibility of Zoonotic Strains. Miotto, Olivo; Heiny, A. T.; Albrecht, Randy; Garcí-Sastre, Adolfo; Tan, Tin Wee; August, J. Thomas; Brusic, Vladimir // PLoS ONE;2010, Vol. 5 Issue 2, p1 

    Background: There is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale...

  • Detection of Resistance Mutations to Antivirals Oseltamivir and Zanamivir in Avian Influenza A Viruses Isolated from Wild Birds. Orozovic, Goran; Orozovic, Kanita; Lennerstrand, Johan; Olsen, Björn // PLoS ONE;2011, Vol. 6 Issue 1, p1 

    The neuraminidase (NA) inhibitors oseltamivir and zanamivir are the first-line of defense against potentially fatal variants of influenza A pandemic strains. However, if resistant virus strains start to arise easily or at a high frequency, a new antiinfluenza strategy will be necessary. This...

  • The Evolutionary Genetics and Emergence of Avian Influenza Viruses in Wild Birds. Dugan, Vivien G.; Chen, Rubing; Spiro, David J.; Sengamalay, Naomi; Zaborsky, Jennifer; Ghedin, Elodie; Nolting, Jacqueline; Swayne, David E.; Runstadler, Jonathan A.; Happ, George M.; Senne, Dennis A.; Ruixue Wang; Slemons, Richard D.; Holmes, Edward C.; Taubenberger, Jeffery K. // PLoS Pathogens;May2008, Vol. 4 Issue 5, p1 

    We surveyed the genetic diversity among avian influenza virus (AIV) in wild birds, comprising 167 complete viral genomes from 14 bird species sampled in four locations across the United States. These isolates represented 29 type A influenza virus hemagglutinin (HA) and neuraminidase (NA) subtype...

  • Be mindful of influenza, even in the spring. Brunell, Philip A. // Infectious Diseases in Children;Apr2008, Vol. 21 Issue 4, p4 

    The author discusses issues of concern regarding influenza immunization. He offered insights on problems such as neuraminidase inhibitors, which have relied on the absence of a vaccine against avian flu and for the treatment of current circulating strains, as well as the logistics of immunizing...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics