TITLE

Potential Anabolic Effects of Androgens on Bone

AUTHOR(S)
Kearns, Ann E.; Khosla, Sundeep
PUB. DATE
April 2004
SOURCE
Mayo Clinic Proceedings;Apr2004 Supplement, Vol. 79 Issue 4, pS14
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Sex steroid hormones are essential to normal skeletal growth and maintenance throughout life in both men and women. The importance of estrogens to bone health in women becomes obvious at menopause when estrogen deficiency occurs and results in accelerated bone loss. After menopause, estrogen deficiency results in drastic changes in the androgen-estrogen ratio. Thus, the relative importance of androgens after menopause may increase. Androgens also appear to be important for bone health in pre-menopausal women. Evidence from human, animal, and laboratory studies is leading to a better understanding of the effects of androgens on bone in women.
ACCESSION #
12733975

 

Related Articles

  • 970. Transcriptional Activation of krox-1 Induced by Sexual Hormones in Osteosarcoma Cells*. Martinez-F., Francisco; Jimenez-O., Fausto A.; Machuca-R., Catalina; Villegas-C., Hilda; Sakamoto, Kathleen // Molecular Therapy;Jun2006, Vol. 13, pS373 

    Transcriptional control of genes delivered by adenoviral vectors in target cells has recovered importance in gene therapy research. Several inductors have been reported to modulate transcriptional activity of krox-1 promoter (EGR-1). Androgens and estrogens activities are identified in muscle...

  • Efficacy of pulsed estrogen therapy in relatively younger patients with surgically induced menopause. N. Yesildaglar; S. Erkaya; D. Uygur; K. Göl; B. Bingöl; Z. Günenç // Human Reproduction;Jan2004, Vol. 19 Issue 1, p210 

    BACKGROUND: Pulsed estrogen therapy is a new approach in estrogen replacement therapy. We carried out a prospective study to evaluate the efficacy of pulsed estrogen therapy in relatively younger patients with surgically induced menopause. METHODS: Patients (n = 138) <45 years old and suffering...

  • A repeated 28-day oral dose toxicity study of methoxychlor in rats, based on the 'Enhanced OECD Test Guideline 407' for screening endocrine-disrupting chemicals. Okazaki, Kazushi; Okazaki, Shuzo; Nishimura, Susumu; Nakamura, Hideaki; Kitamura, Yasuki; Hatayama, Kazuhisa; Nakamura, Atushi; Tsuda, Toshiharu; Katsumata, Tomoyoshi; AkiyoshiNishikawa; Hirose, Masao // Archives of Toxicology;Nov2001, Vol. 75 Issue 9, p513 

    In association with the international validation project to establish an OECD Enhanced Test Guideline 407, we performed a 28-day repeated-dose toxicity study of methoxychlor, a chlorinated hydrocarbon pesticide with pro-estrogenic and anti-androgenic activities. Attention was paid to the...

  • The Effect of Neurosteroids on Depression in Peri-menopausal Women. Bronson, Phyllis J. // Journal of Orthomolecular Medicine;2005 3rd Quarter, Vol. 20 Issue 3, p210 

    The article examines the effect of neurosteroids on depression in peri-menopausal women. In the original study 12 women in late peri-menopause were followed over four years. The original subjects were divided according to emotional and mood evaluations, including our own peri-menopause mood...

  • Socioeconomic influences on bone health in postmenopausal women: findings from NHANES III, 1988–1994. May-Choo Wang; Dixon, L. Beth // Osteoporosis International;Jan2006, Vol. 17 Issue 1, p91 

    Our objectives were (1) to examine the associations of education and income with bone health in non-Hispanic White, non-Hispanic Black and Mexican-American postmenopausal women, (2) to determine if any observed associations can be explained by behavioral factors such as calcium intake and...

  • The Aging Ovary. Shifren, Jan L.; Schiff, Isaac // Journal of Women's Health & Gender-Based Medicine;Jan2000 Supplement 1, Vol. 9 Issue 1, p3 

    During reproductive life, ovarian steroid biosynthesis is gonadotropin dependent and occurs in theca and granulosa cells. In the menopausal ovary, there is atresia of ovarian follicles, with sparing of the androgen-producing theca-interstitial cell component. The aging ovary, therefore, produces...

  • Turner Syndrome: Transition from Pediatrics to Adulthood.  // Endocrine Practice;Sep2008, Vol. 14 Issue 6, p775 

    Objective: To highlight the importance of an improved, seamless, and effective transition from pediatric to adult care, especially for medically complex conditions such as Turner syndrome (TS).Methods: The morbidities in adult patients with TS are reviewed, including features of the metabolic...

  • Hot Flashes and Androgens: A Biological Rationale for Clinical Practice. Notelovitz, Morris // Mayo Clinic Proceedings;Apr2004 Supplement, Vol. 79 Issue 4, pS8 

    Hot flashes are the most prevalent symptom of menopause. Although the etiology of hot flashes has yet to be determined, it is increasingly apparent that the physiology of the underlying vasomotor instability is multifactorial. Estrogen and androgen receptors are present in the areas of the...

  • an·dro·gen.  // American Heritage Student Science Dictionary;2009, p15 

    A definition of the term "androgen" is presented. It refers to any of several steroid hormones, such as testosterone, that control the development and maintenance of physical characteristics in males.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics