Hot Flashes and Androgens: A Biological Rationale for Clinical Practice

Notelovitz, Morris
April 2004
Mayo Clinic Proceedings;Apr2004 Supplement, Vol. 79 Issue 4, pS8
Academic Journal
Hot flashes are the most prevalent symptom of menopause. Although the etiology of hot flashes has yet to be determined, it is increasingly apparent that the physiology of the underlying vasomotor instability is multifactorial. Estrogen and androgen receptors are present in the areas of the central nervous system relevant to hot flashes. Androgens are central to the synthesis of estrogen and to the bioavailability of free estrogen in peripheral tissues. In addition, androgens have direct central nervous system effects that modulate other endocrine factors associated with hot flashes. The pharmacodynamic differences of testosterone and methyltestosterone are briefly reviewed in the context of choice for individualized clinical use.


Related Articles

  • an·dro·gen.  // American Heritage Student Science Dictionary;2009, p15 

    A definition of the term "androgen" is presented. It refers to any of several steroid hormones, such as testosterone, that control the development and maintenance of physical characteristics in males.

  • Androgen. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p14 

    This article offers information about androgen. Also known as testosterone, androgens are steroid hormones found in the testes. One factor influencing the biological activity of the androgens is described.

  • Andropatch.  // Royal Society of Medicine: Medicines;2002, p61 

    The article provides information on Andropatch, a proprietary, prescription-only preparation of the androgen testosterone from GlaxoSmithKline. It can be used to treat testosterone deficiency in men, and is available in the form of skin patches.

  • Defending the brain from estrogen. Puts, David A.; Jordan, Cynthia L.; Breedlove, S. Marc // Nature Neuroscience;Feb2006, Vol. 9 Issue 2, p155 

    The article reports on the study which found that alpha-fetoprotein inhibits estrogen activity in females. The study suggests that one must first realize that in rats and mice it is not testosterone itself that masculinizes the developing brain, but rather metabolites of testosterone: estrogens...

  • The effects of endogenous and exogenous androgens on cardiovascular disease risk factors and progression. Manolakou, Panagiota; Angelopoulou, Roxani; Bakoyiannis, Chris; Bastounis, Elias // Reproductive Biology & Endocrinology;2009, Vol. 7, p1 

    Cardiovascular disease incidence rates have long been known to significantly differ between the two sexes. Estrogens alone fail to explain this phenomenon, bringing an increasing amount of attention to the role of androgens. Contrary to what was initially hypothesized, androgens seem to have an...

  • Potential Anabolic Effects of Androgens on Bone. Kearns, Ann E.; Khosla, Sundeep // Mayo Clinic Proceedings;Apr2004 Supplement, Vol. 79 Issue 4, pS14 

    Sex steroid hormones are essential to normal skeletal growth and maintenance throughout life in both men and women. The importance of estrogens to bone health in women becomes obvious at menopause when estrogen deficiency occurs and results in accelerated bone loss. After menopause, estrogen...

  • Midlife Women's Attributions about Perceived Memory Changes: Observations from the Seattle Midlife Women's Health Study. Mitchell, Ellen Sullivan; Woods, Nancy Fugate // Journal of Women's Health & Gender-Based Medicine;May2001, Vol. 10 Issue 4, p351 

    Memory changes are of increasing interest as midlife women approach menopause. Recent studies of relationships between estrogen and Alzheimer's disease have prompted interest in memory experiences around the time of menopause. The purpose of this analysis, part of the larger Seattle Midlife...

  • Influence of Androgens on Circulating Adiponectin in Male and Female Rodents. Yarrow, Joshua F.; Beggs, Luke A.; Conover, Christine F.; McCoy, Sean C.; Beck, Darren T.; Borst, Stephen E. // PLoS ONE;Oct2012, Vol. 7 Issue 10, Special section p1 

    Several endocrine factors, including sex-steroid hormones are known to influence adiponectin secretion. Our purpose was to evaluate the influence of testosterone and of the synthetic non-aromatizable/non-5α reducible androgen 17β-hydroxyestra-4,9,11-trien-3-one (trenbolone) on circulating...

  • Circulating sex steroids, sex hormone-binding globulin, and longitudinal changes in forearm bone mineral density in postmenopausal women and men: the Tromsø study. Bjørnerem, Åshild; Emaus, Nina; Berntsen, Gro; Joakimsen, Ragnar M.; Fønnebø, Vinjar; Wilsgaard, Tom; Øian, Pål; Seeman, Ego; Straume, Bjørn; Bjørnerem, Ashild; Berntsen, Gro K R; Fønnebø, Vinjar; Oian, Pål; Straume, Bjørn // Calcified Tissue International;Aug2007, Vol. 81 Issue 2, p65 

    Bone loss during advancing age in women and men is partly the result of sex steroid deficiency. As the contribution of circulating sex steroids and sex hormone-binding globulin (SHBG) to bone loss remains uncertain, we sought to determine whether levels of sex steroids or SHBG predict change in...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics