TITLE

Oxidants and asthma

AUTHOR(S)
Caramori G; Papi A
PUB. DATE
February 2004
SOURCE
Thorax;Feb2004, Vol. 59 Issue 2, p170
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Many decades of research have produced a significant amount of data showing increased oxidative stress in asthma and indicating a potential role for oxidants in the pathogenesis of the disease, particularly during exacerbations. Putatively relevant pro-oxidative mechanisms have also been identified. Currently available asthma drugs are generally effective for the treatment of the disease, but their effects on oxidative stress have still not been completely elucidated. From the data available in the literature one can conclude that antioxidant compounds may have a potential role in the treatment of asthma, especially of asthma exacerbations. More convincing evidence from controlled clinical trials is required.
ACCESSION #
12653839

 

Related Articles

  • How to Move From Belief to Proof? Articulating the Value of Chronic Disease and Care Management Programs for Adults With Asthma. Steuten, Lotte M. G. // Respiratory Care;Jul2009, Vol. 54 Issue 7, p844 

    The article reflects on the significance and limitations of the study about the value of chronic disease and care management programs for adults suffering from asthma conducted by Matthew L. Maciejewski. The author indicates that Maciejewski sees that more randomized controlled trials need to be...

  • Detailed postal feedback about prescribing to asthma patients combined with a guideline statement showed no impact: a randomised controlled trial. Søndergaard, Jens; Andersen, Morten; Vach, Kirstin; Kragstrup, Jakob; Maclure, Malcolm; Gram, Lars F. // European Journal of Clinical Pharmacology;May2002, Vol. 58 Issue 2, p127 

    Objective. To evaluate the effects of postal feedback with clinically relevant data on general practitioners' prescribing compared with feedback with aggregate data on prescribing patterns of asthma drugs. Methods. The study was a randomised, controlled trial. The general practitioners (GPs) in...

  • Daily corticosteroids were not better than as-needed corticosteroids in mild persistent asthma.  // ACP Journal Club;Nov/Dec2005, Vol. 143 Issue 3, p60 

    This article presents information on a clinical study according to which daily corticosteroids were not better than as-needed corticosteroids in mild persistent asthma. This study explored that in patients with mild persistent asthma, how does intermittent, short-course corticosteroid treatment...

  • Obtaining real-world evidence: the Salford Lung Study. New, John P.; Bakerly, Nawar Diar; Leather, David; Woodcock, Ashley // Thorax;Dec2014, Vol. 69 Issue 12, p1152 

    We need to assess clinical treatments in real-life settings outside of randomised controlled trials (RCTs). Pragmatic RCT (pRCT) data can supplement RCTs by providing effectiveness information to support healthcare decisions. Electronic health records can facilitate concurrent safety monitoring...

  • Patients with Asthma and Comorbid Allergic Rhinitis: Is Optimal Quality of Life Achievable in Real Life? Braido, Fulvio; Baiardini, Ilaria; Menoni, Stefania; Gani, Federica; Senna, Gian Enrico; Ridolo, Erminia; Schoepf, Veruska; Rogkakou, Anthi; Canonica, Giorgio Walter // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Objectives: Asthma trials suggest that patients reaching total disease control have an optimal Health Related Quality of Life (HRQoL). Moreover, rhinitis is present in almost 80% of asthmatics and impacts asthma control and patient HRQoL. We explored whether optimal HRQoL was reachable in a...

  • Is nedocromil effective in preventing asthmatic attacks in patients with asthma? Dudley, Tim; Parker, Sandi // Journal of Family Practice;Nov2004, Vol. 53 Issue 11, p927 

    This article investigates the effectiveness of nedocromil in preventing asthmatic attacks in patients with asthma. A systematic review encompassing trial centers and patients concluded that inhaled nedocromil was effective for a variety of patients with asthma. It is noted that nedocromil is...

  • Double blind randomised controlled trial of two different breathing techniques in the management of asthma. Slader, C. A.; Reddel, H. K.; Spencer, L. M.; Belousova, E. G.; Armour, C. L.; Bosnic-Anticevich, S. Z.; Thien, F. C. K.; Jenkins, C. R. // Thorax;Aug2006, Vol. 61 Issue 8, p651 

    Background: Previous studies have shown that breathing techniques reduce short acting β2 agonist use and improve quality of life (QoL) in asthma. The primary aim of this double blind study was to compare the effects of breathing exercises focusing on shallow nasal breathing with those of...

  • Potential role of Cryptococcusneoformans in the pathogenesis of asthma. Nachrnan, S. A. // Thorax;Aug2006, Vol. 61 Issue 8, p705 

    The article investigates the potential role of cryptococcusneoformans in the pathogenesis of asthma. Active pulmonary cryptococcal infection may enhance allergic response with Th2 polarization and increased airway responsiveness in rats. It has been suggested that epidemiological studies are...

  • Oxidant-induced corticosteroid unresponsiveness in human bronchial epithelial cells. Heijink, Irene; van Oosterhout, Antoon; Kliphuis, Nathalie; Jonker, Marnix; Hoffmann, Roland; Telenga, Eef; Klooster, Karin; Slebos, Dirk-Jan; Hacken, Nick ten; Postma, Dirkje; van den Berge, Maarten // Thorax;Jan2014, Vol. 69 Issue 1, p5 

    Background We hypothesised that increased oxidative stress, as present in the airways of asthma and chronic obstructive pulmonary disease (COPD) patients, induces epithelial damage and reduces epithelial responsiveness to suppressive effects of corticosteroids on proinflammatory cytokine...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics