TITLE

The exercise test as a monitor of disease status in hypokalaemic periodic paralysis

AUTHOR(S)
Tengan C H; Antunes A C; Gabbai A A; Manzano G M; Tengan, C H; Antunes, A C; Gabbai, A A; Manzano, G M
PUB. DATE
March 2004
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Mar2004, Vol. 75 Issue 3, p497
SOURCE TYPE
Academic Journal
DOC. TYPE
journal article
ABSTRACT
Objective: To evaluate exercise test responses in hypokalaemic periodic paralysis (HPP), to determine its value as a diagnostic tool and the factors that could affect the responses.Methods: 22 subjects were studied from two families with HPP caused by R528H mutation, four patients with thyrotoxic periodic paralysis, 15 normal controls, and four controls with hyperthyroidism. All family members were submitted to clinical evaluation, electrophysiological exercise testing, and DNA analysis. Patients with thyrotoxic periodic paralysis had exercise tests before and after treatment of their hyperthyroidism.Results: Abnormal responses to the exercise tests were obtained only in subjects with recent attacks of weakness. They were not correlated with genotype, as asymptomatic carriers were unaffected. Patients with thyrotoxic periodic paralysis showed pronounced impairment while they were hyperthyroid, but improved when they were euthyroid. One patient with HPP and chronic KCl use had an increase in amplitude potentials over approximately 20 minutes, possibly related to alteration of potassium homeostasis.Conclusions: The exercise test is a useful diagnostic test for periodic paralysis, but in the absence of recent weakness negative results must be viewed with caution. It has advantages over the DNA test in being a non-invasive functional test that can provide insights into abnormalities of muscle excitability.
ACCESSION #
12653778

 

Related Articles

  • Parálisis periódica hipokalémica tirotóxica: reporte de un caso y revisión tema. Acevedo Rueda, Sandra Milena; Rincón Albarrán, Luz Ángela // MedUNAB;abr-jul2013, Vol. 16 Issue 1, p39 

    We describe a case of a 20 years old man, who consulted to the emergency room for two hours of paresthesias and loss of muscle strength In the lower limbs, until he presented complete Inability to rise from a chair. During the last two months, the patient presented five episodes similar to this,...

  • Thyrotoxic Periodic Paralysis. Shih-Hua Lin // Mayo Clinic Proceedings;Jan2005, Vol. 80 Issue 1, p99 

    Thyrotoxic periodic paralysis (TPP), a hyperthyroidism-related hypokalemia and muscle-weakening condition resulting from a sudden shift of potassium into cells, has been seen increasingly in Western countries. Failure to recognize TPP may lead to improper management. Many patients with TPP have...

  • Thyrotoxic periodic paralysis in a 14-year-old boy. Wong, Gary Wing-Kin; Leung, Ting Fan; Lo, Amy Fung-Cheung; Ahuja, Anil T.; Cheng, Pik Shun // European Journal of Pediatrics;2000, Vol. 159 Issue 12, p934 

    Presents the case of an adolescent boy who had thyrotoxic periodic paralysis. Blood and electrolyte levels; Association between thyrotoxicosis and periodic paralysis; Cause of familial hypokalaemic periodic paralysis.

  • Isolated Left Oculomotor Nerve Palsy Following Measles. Caksen, Huseyin // Journal of Child Neurology;Oct2002, Vol. 17 Issue 10, p784 

    A 10-month-old boy was admitted with ptosis on the left eyelid, which rapidly occurred following a disease with rash about 20 days before admission to our hospital. By history, none of the vaccinations had been performed. On physical examination, his vital signs were stable, and he had marasmus....

  • familial periodic paralysis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p846 

    An encyclopedia entry for "familial periodic paralysis" is presented.

  • Moebius syndrome.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1481 

    A definition of the term "Moebius syndrome," which refers to the congenital paralysis of the facial nerve, is presented.

  • monomyoplegia.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1488 

    A definition of the medical term "monomyoplegia," which refers to the paralysis of only one muscle, is presented.

  • monoparesis.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p1489 

    A definition of the medical term "monoparesis," which refers to paralysis of a single part of the body, is presented.

  • Villaret's syndrome.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p2462 

    A definition of the term "Villaret's syndrome" which refers to ipsilateral paralysis is presented.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics