TITLE

Genomic analyses reveal low mitochondrial and high nuclear diversity in the cyclosporin-producing fungus Tolypocladium inflatum

AUTHOR(S)
Zhang, Yong-Jie; Yang, Xiao-Qing; Zhang, Shu; Humber, Richard; Xu, Jianping
PUB. DATE
December 2017
SOURCE
Applied Microbiology & Biotechnology;Dec2017, Vol. 101 Issue 23/24, p8517
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Mitochondrial DNA is generally regarded to evolve faster than nuclear DNA in animals, whereas if this is also true in fungi remains unclear. Herein, we annotate the first complete mitochondrial genome (mitogenome) of the cyclosporin-producing fungus Tolypocladium inflatum and report the genome-wide sequence variations among five isolates originating from distantly separated localities. We found that T. inflatum has among the most compact of fungal mitogenomes; its 25 kb DNA molecule encodes all standard fungal mitochondrial genes and harbors only one intron. Transcriptional analyses validated the expression of most conserved genes. We found several uncommon repetitive elements and evidence of gene transfer from the mitochondrion to the nucleus. Phylogenetic analyses confirmed the placement of T. inflatum in the fungal order Hypocreales although there was uncertainty on its family-level affiliation. Comparative genomic analyses among the five isolates identified an overall lower level of intraspecific variation in mitogenomes than in nuclear genomes; however, both the nuclear and mitochondrial genomes revealed similar isolate relationships, not correlating with geographic sources of these isolates. Our study shed new insights into the evolution of the medicinally important ascomycete T. inflatum.
ACCESSION #
126307863

 

Related Articles

  • Fast-Evolving Mitochondrial DNA in Ceriantharia: A Reflection of Hexacorallia Paraphyly? Stampar, Sérgio N.; Maronna, Maximiliano M.; Kitahara, Marcelo V.; Reimer, James D.; Morandini, André C. // PLoS ONE;Jan2014, Vol. 9 Issue 1, p1 

    The low evolutionary rate of mitochondrial genes in Anthozoa has challenged their utility for phylogenetic and systematic purposes, especially for DNA barcoding. However, the evolutionary rate of Ceriantharia, one of the most enigmatic “orders” within Anthozoa, has never been...

  • A Preliminary Molecular Phylogeny of Planthoppers (Hemiptera: Fulgoroidea) Based on Nuclear and Mitochondrial DNA Sequences. Song, Nan; Liang, Ai-Ping // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    The planthopper superfamily Fulgoroidea (Insecta: Hemiptera) is one of the most dominant groups of phytophagous insects. It comprises about 20 families, containing a total of 9000 species worldwide. Despite several recent studies, the phylogeny of Fulgoroidea is not yet satisfactorily resolved...

  • The Complete Mitochondrial Genomes of Two Octopods Cistopus chinensis and Cistopus taiwanicus: Revealing the Phylogenetic Position of the Genus Cistopus within the Order Octopoda. Cheng, Rubin; Zheng, Xiaodong; Ma, Yuanyuan; Li, Qi // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    In the present study, we determined the complete mitochondrial DNA (mtDNA) sequences of two species of Cistopus, namely C. chinensis and C. taiwanicus, and conducted a comparative mt genome analysis across the class Cephalopoda. The mtDNA length of C. chinensis and C. taiwanicus are 15706 and...

  • Lake Mungo 3: A response to recent critiques. Adcock, Gregory J.; Dennis, Elizabeth S.; Easteal, Simon; Huttley, Gavin A.; Jermiin, Lars S.; Peacock, W. James; Thorne, Alan // Archaeology in Oceania;Oct2001, Vol. 36 Issue 3, p170 

    Details the response on the phylogenetic analysis of the mitochondrial DNA from a number of ancient Australian individuals raised by various authors. Way of interpreting the data; Removal of potential contaminant DNA; Treatment of solutions using ultraviolet lights and silica.

  • Molecular Phylogeny of Red-Backed Voles in Far East Asia Based on Variation in Ribosomal and... Suzuki, Hitoshi; Iwasa, Masahiro // Journal of Mammalogy;May99, Vol. 80 Issue 2, p512 

    Examines the nuclear ribosomal DNA (rDNA) and mitochondrial DNA (mtDNA) variations to explore the phylogenetic relationships among various species of red-backed voles Clethrionomys and Eotheonomys from areas surrounding the Sea of Japan. List of samples of voles of Clethrionomys and Eotheonomys...

  • Deducing the pattern of arthropod phylogeny from mitochondrial DNA rearrangements. Boore, Jeffrey L.; Collins, Timothy M. // Nature;7/13/1995, Vol. 376 Issue 6536, p163 

    Examines the origins of arthropods and the phylogenetic relationships among their three major living groups using data from mitochondrial DNA rearrangements. Gene arrangement comparisons as a new tool for resolving ancient phylogenetic relationships.

  • Mitochondrial DNA Heritage of Cres Islanders -- Example of Croatian Genetic Outliers. Jeran, Nina; Auguštin, Dubravka Havaš; Grahovac, Blazenka; Kapović, Miljenko; Metspalu, Ene; Villems, Richard; Rudan, Pavao // Collegium Antropologicum;Dec2009, Vol. 33 Issue 4, p1323 

    Diversity of mitochondrial DNA (mtDNA) lineages of the Island of Cres was determined by high-resolution phylogenetic analysis on a sample of 119 adult unrelated individuals from eight settlements. The composition of mtDNA pool of this Island population is in contrast with other Croatian and...

  • Evidence for an African Cluster of Human Head and Body Lice with Variable Colors and Interbreeding of Lice between Continents. Veracx, Aurélie; Boutellis, Amina; Merhej, Vicky; Diatta, Georges; Raoult, Didier // PLoS ONE;May2012, Vol. 7 Issue 5, p1 

    Background: Human head lice and body lice have been classified based on phenotypic characteristics, including geographical source, ecotype (preferred egg laying site hair or clothes), shape and color. More recently, genotypic studies have been based on mitochondrial genes, nuclear genes and...

  • Arrival of Paleo-Indians to the Southern Cone of South America: New Clues from Mitogenomes. de Saint Pierre, Michelle; Gandini, Francesca; Perego, Ugo A.; Bodner, Martin; Gómez-Carballa, Alberto; Corach, Daniel; Angerhofer, Norman; Woodward, Scott R.; Semino, Ornella; Salas, Antonio; Parson, Walther; Moraga, Mauricio; Achilli, Alessandro; Torroni, Antonio; Olivieri, Anna // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    With analyses of entire mitogenomes, studies of Native American mitochondrial DNA (mtDNA) variation have entered the final phase of phylogenetic refinement: the dissection of the founding haplogroups into clades that arose in America during and after human arrival and spread. Ages and geographic...

  • The mitochondrial DNA of land plants: peculiarities in phylogenetic perspective. Knoop, Volker // Current Genetics;Sep2004, Vol. 46 Issue 3, p123 

    Land plants exhibit a significant evolutionary plasticity in their mitochondrial DNA (mtDNA), which contrasts with the more conservative evolution of their chloroplast genomes. Frequent genomic rearrangements, the incorporation of foreign DNA from the nuclear and chloroplast genomes, an ongoing...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics