Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate

Fujiki, Hirota; Sueoka, Eisaburo; Rawangkan, Anchalee; Suganuma, Masami
December 2017
Journal of Cancer Research & Clinical Oncology;Dec2017, Vol. 143 Issue 12, p2401
Academic Journal
Purpose: Our previous experiments show that the main constituent of green-tea catechins, (−)-epigallocatechin gallate (EGCG), completely prevents tumor promotion on mouse skin initiated with 7,12-dimethylbenz(a)anthracene followed by okadaic acid and that EGCG and green tea extract prevent cancer development in a wide range of target organs in rodents. Therefore, we focused our attention on human cancer stem cells (CSCs) as targets of cancer prevention and treatment with EGCG. Methods: The numerous reports concerning anticancer activity of EGCG against human CSCs enriched from cancer cell lines were gathered from a search of PubMed, and we hope our review of the literatures will provide a broad selection for the effects of EGCG on various human CSCs. Results: Based on our theoretical study, we discuss the findings as follows: (1) Compared with the parental cells, human CSCs express increased levels of the stemness markers Nanog, Oct4, Sox2, CD44, CD133, as well as the EMT markers, Twist, Snail, vimentin, and also aldehyde dehydrogenase. They showed decreased levels of E-cadherin and cyclin D1. (2) EGCG inhibits the transcription and translation of genes encoding stemness markers, indicating that EGCG generally inhibits the self-renewal of CSCs. (3) EGCG inhibits the expression of the epithelial-mesenchymal transition phenotypes of human CSCs. (4) The inhibition of EGCG of the stemness of CSCs was weaker compared with parental cells. (5) The weak inhibitory activity of EGCG increased synergistically in combination with anticancer drugs. Conclusions: Green tea prevents human cancer, and the combination of EGCG and anticancer drugs confers cancer treatment with tissue-agnostic efficacy.


Related Articles

  • Metabolic Profiling-based Data-mining for an Effective Chemical Combination to Induce Apoptosis of Cancer Cells. Kumazoe, Motofumi; Fujimura, Yoshinori; Hidaka, Shiori; Kim, Yoonhee; Murayama, Kanako; Takai, Mika; Huang, Yuhui; Yamashita, Shuya; Murata, Motoki; Miura, Daisuke; Wariishi, Hiroyuki; Maeda-Yamamoto, Mari; Tachibana, Hirofumi // Scientific Reports;3/27/2015, p9474 

    Green tea extract (GTE) induces apoptosis of cancer cells without adversely affecting normal cells. Several clinical trials reported that GTE was well tolerated and had potential anti-cancer efficacy. Epigallocatechin-3-O-gallate (EGCG) is the primary compound responsible for the anti-cancer...

  • Cancer stem cells: an evolving concept. Nguyen, Long V.; Vanner, Robert; Dirks, Peter; Eaves, Connie J. // Nature Reviews Cancer;Feb2012, Vol. 12 Issue 2, p133 

    The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. This idea is not new, but has recently gained prominence because of advances in defining...

  • EGCG inhibits properties of glioma stem-like cells and synergizes with temozolomide through downregulation of P-glycoprotein inhibition. Zhang, Yong; Wang, Shao-Xiang; Ma, Ji-Wei; Li, Hai-Ying; Ye, Jie-Cheng; Xie, Si-Ming; Du, Bin; Zhong, Xue-Yun // Journal of Neuro-Oncology;Jan2015, Vol. 121 Issue 1, p41 

    Rational: Combination therapy to inhibit cancer stem cells may have important clinical implications. Here, we examine the molecular mechanisms by which epigallocatechin gallate (EGCG), a bioactive polyphenol in green tea, inhibits the stem cell characteristics of glioma stem-like cells (GSLCs)...

  • EGCG Suppresses Lung Cancer Cell Growth. Finkel, Jon // Life Extension;Aug2010, Vol. 16 Issue 8, p14 

    The article discusses research which was conducted at the Hormel Institute at the University of Minnesota and found that a polyphenol compound in the catechin family called epigallocatechin gallate, which is found in green tea, may help stop the growth of lung cancer.

  • Tocotrienol-Rich Fraction, [6]-Gingerol and Epigallocatechin Gallate Inhibit Proliferation and Induce Apoptosis of Glioma Cancer Cells. Abdul Rahman, Amirah; Makpol, Suzana; Jamal, Rahman; Harun, Roslan; Mokhtar, Norfilza; Wan Ngah, Wan Zurinah // Molecules;Sep2014, Vol. 19 Issue 9, p14528 

    Plant bioactives [6]-gingerol (GING), epigallocatechin gallate (EGCG) and asiaticoside (AS) and vitamin E, such as tocotrienol-rich fraction (TRF), have been reported to possess anticancer activity. In this study, we investigated the apoptotic properties of these bioactive compounds alone or in...

  • Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Gupta, Subash C.; Ji Hye Kim; Prasad, Sahdeo; Aggarwal, Bharat B. // Cancer & Metastasis Reviews;Sep2010, Vol. 29 Issue 3, p405 

    lmost 25 centuries ago, Hippocrates, the father of medicine, proclaimed “Let food be thy medicine and medicine be thy food.” Exploring the association between diet and health continues today. For example, we now know that as many as 35% of all cancers can be prevented by dietary...

  • Cell-based Delivery of Oncolytic Viruses: A New Strategic Alliance for a Biological Strike Against Cancer. Power, Anthony T.; Bell, John C. // Molecular Therapy;Apr2007, Vol. 15 Issue 4, p660 

    Recent years have seen tremendous advances in the development of exquisitely targeted replicating virotherapeutics that can safely destroy malignant cells. Despite this promise, clinical advancement of this powerful and unique approach has been hindered by vulnerability to host defenses and...

  • Cancer biology: Kicking out cancer cells.  // Nature;1/14/2010, Vol. 463 Issue 7278, p138 

    The article reports on the study conducted by Yasuyuki Fujita and colleagues of University College London regarding the technique of detecting cancer cells in London, England. It suggests that healthy cells can detect the transformation of the cancerous cells. It also found that proteins, such...

  • Evolutionary Dynamics of Intratumor Heterogeneity. Iwasa, Yoh; Michor, Franziska // PLoS ONE;2011, Vol. 6 Issue 3, p1 

    Intraneoplastic diversity in human tumors is a widespread phenomenon of critical importance for tumor progression and the response to therapeutic intervention. Insights into the evolutionary events that control tumor heterogeneity would be a major breakthrough in our comprehension of cancer...

  • The HSP90 inhibitor 17-PAG effectively inhibits the proliferation and migration of androgen-independent prostate cancer cells. Ruixian Peng; Zhenyu Li; Zhiyuan Lin; Yang Wang; Wei Wang; Bo Hu; Xilong Wang; Jun Zhang; Yangyun Wang; Renyuan Zhou; Chunhua Lu; Yuemao Shen; Jifeng Wang; Guowei Shi // American Journal of Cancer Research;2015, Vol. 5 Issue 10, p3198 

    Castration-resistant prostate cancer (CRPC) ultimately occurs after a period of treatment with androgen deprivation therapy. Furthermore, CRPC patients can only derive limited survival benefits from traditional cytotoxic drugs. HSP90, which is a molecular chaperone, plays a vital role in client...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics