Efficacy of PDE5Is and SSRIs in men with premature ejaculation: a new systematic review and five meta-analyses

Sun, Yi; Yang, Lu; Bao, Yige; Liu, Zhenhua; Liu, Liangren; Wei, Qiang
December 2017
World Journal of Urology;Dec2017, Vol. 35 Issue 12, p1817
Academic Journal
Purpose: To clarify the efficacy of phosphodiesterase-5 inhibitors (PDE5Is) and selective serotonin reuptake inhibitors (SSRIs) in men with premature ejaculation (PE). Methods: We searched the PubMed, Embase, and Cochrane Library databases to identify all randomized, controlled trials (RCTs) and compared the results, including intravaginal ejaculation latency time, satisfaction, intercourse per-week and side effects after treatment with PDE5I or SSRIs versus placebo, combined use of PDE5I with SSRIs versus PDE5I or SSRIs alone, and PDE5I versus SSRIs for treating PE. Results: The study inclusion criteria were met by 23 studies (ten RCTs with five crossover studies) involving 6145 patients. The data synthesized from these studies indicated that the efficacy of PDE5Is and SSRIs was better than that of placebo ( p < 0.00001; p < 0.00001); however, more patients had side effects while taking PDE5Is and SSRIs ( p < 0.00001; p < 0.00001). The efficacy of the combined treatment was significantly better than that of PDE5Is or SSRIs alone ( p < 0.00001; p < 0.00001); however, more patients had side effects from the combined treatment than from SSRIs ( p = 0.0002), with no significant difference in PDE5Is ( p = 0.5). The efficacy of PDE5Is was better than that of SSRIs ( p = 0.006), and no significant difference was observed in the frequency of side effects ( p = 0.93). Conclusions: PDE5Is were significantly more effective than placebo or SSRIs for treating PE, while SSRIs were better than placebo. The combined treatment had better efficacy than PDE5Is or SSRIs alone.


Related Articles

  • Dapoxetine. Feret, Brett // Formulary;Jul2005, Vol. 40 Issue 7, p227 

    Dapoxetine (Alza/Ortho-McNeil) is a novel oral medication undergoing FDA review for premature ejaculation, one of the most common disorders of sexual dysfunction in men. Dapoxetine is a fast-acting inhibitor of the serotonin reuptake transporter. It has a short half-life and is structurally...

  • A Benefit-Risk Assessment of Dapoxetine in the Treatment of Premature Ejaculation. Hutchinson, Kate; Cruickshank, Kelly; Wylie, Kevan // Drug Safety;2012, Vol. 35 Issue 5, p359 

    Premature ejaculation (PE) is considered to be the most common sexual problem affecting men, despite the likelihood that it is under-diagnosed. It is a complex condition with many physical and psychological components, making management complicated. It is important to develop treatments for PE...

  • Tratamiento de la eyaculación precoz. Punto de vista del internista. Velasco, Jorge Aldrete; Janeiro Sarabia, Manuel Ramón; Aldrete Audiffred, Sol del Mar // Medicina Interna de Mexico;sep/oct2010, Vol. 26 Issue 5, p485 

    No abstract available.

  • The drug that helps men last longer. Hooper, Rowan // New Scientist;9/16/2006, Vol. 191 Issue 2569, p12 

    This article focuses on different issues related to drugs for premature ejaculation. A new drug dapoxetine, a selective serotonin reuptake inhibitor, is being tested for its effectiveness. Jon Pryor at the University of Minnesota, Minneapolis, says that the drug improved patients' satisfaction...

  • Adverse Effects on Semen from SSRI Treatment of Premature Ejaculation.  // Neurology Alert;Feb2012 Clinical Brief, p1 

    The article discusses research on the effect of selective serotonin reuptake inhibitors (SSRIs) in the control of premature ejaculation (pEJ), referencing a study by H. Koyuncu et al, published in a 2011 issue of "International Journal of Impotence Research."

  • Adverse Effects on Semen from SSRI Treatment of Premature Ejaculation. Kuritzky, Louis // Internal Medicine Alert;1/15/2012 Supplement, p7 

    The article discusses a study which found that sustained use of selective serotonin reuptake inhibitors (SSRI) for the treatment of premature ejaculation has adverse effects on semen.

  • Adverse Effects on Semen from SSRI Treatment of Premature Ejaculation. Kuritzky, Louis // Infectious Disease Alert;Feb2012 Clinical Briefs, p3 

    The article discusses research by H. Koyuncu and colleagues, published in a 2011 issue of "International Journal of Impotence Research" on the effects of using selective serotonin reuptake inhibitors (SSRIs) to treat premature ejaculation.

  • Men with premature ejaculation respond well to SSRIs. Guttman, Cheryl // Urology Times;Apr2003, Vol. 31 Issue 4, p43 

    Discusses a study showing that men with acquired and lifelong premature ejaculation respond equally well in the short term to various selective serotonin re-uptake inhibitor (SSRI) drugs. Differences in long-term therapeutic responses; Likelihood for achieving restoration of ejaculatory control...

  • Antidepressants take worry out of premature ejaculation.  // Urology Times;Jan97, Vol. 25 Issue 1, p20 

    Reports that low doses of selective serotonin reuptake inhibitors (SSRIs) may help some patients achieve better ejaculatory control and improved satisfaction with sexual intercourse. Prescription of SSRI's to treat depression and related mood disorders; Low dose tablet formulation for...

  • Salvage Use of Citalopram for Treatment of Fluoxetine-Resistant Premature Ejaculation in Recently Married Men A Prospective Clinical Trial. Dadfar, Mohammad Reza; Baghinia, Mahmood Reza // Urology Journal;Nov2010, Vol. 7 Issue 1, p40 

    Introduction: A wide variety of therapeutic modalities have been tried for treatment of premature ejaculation. Selective serotonin reuptake inhibitors are from the latest and most effective medical agents. Among these drugs, fluoxetine hydrochloride has been used for some years in our...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics