TITLE

High Cholesterol/Low Cholesterol: Effects in Biological Membranes: A Review

AUTHOR(S)
Subczynski, Witold; Pasenkiewicz-Gierula, Marta; Widomska, Justyna; Mainali, Laxman; Raguz, Marija
PUB. DATE
December 2017
SOURCE
Cell Biochemistry & Biophysics;Dec2017, Vol. 75 Issue 3/4, p369
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Lipid composition determines membrane properties, and cholesterol plays a major role in this determination as it regulates membrane fluidity and permeability, as well as induces the formation of coexisting phases and domains in the membrane. Biological membranes display a very diverse lipid composition, the lateral organization of which plays a crucial role in regulating a variety of membrane functions. We hypothesize that, during biological evolution, membranes with a particular cholesterol content were selected to perform certain functions in the cells of eukaryotic organisms. In this review, we discuss the major membrane properties induced by cholesterol, and their relationship to certain membrane functions.
ACCESSION #
126260632

 

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