Short-term depression and transient memory in sensory cortex

Gillary, Grant; Heydt, Rüdiger von der; Niebur, Ernst
December 2017
Journal of Computational Neuroscience;Dec2017, Vol. 43 Issue 3, p273
Academic Journal
Persistent neuronal activity is usually studied in the context of short-term memory localized in central cortical areas. Recent studies show that early sensory areas also can have persistent representations of stimuli which emerge quickly (over tens of milliseconds) and decay slowly (over seconds). Traditional positive feedback models cannot explain sensory persistence for at least two reasons: (i) They show attractor dynamics, with transient perturbations resulting in a quasi-permanent change of system state, whereas sensory systems return to the original state after a transient. (ii) As we show, those positive feedback models which decay to baseline lose their persistence when their recurrent connections are subject to short-term depression, a common property of excitatory connections in early sensory areas. Dual time constant network behavior has also been implemented by nonlinear afferents producing a large transient input followed by much smaller steady state input. We show that such networks require unphysiologically large onset transients to produce the rise and decay observed in sensory areas. Our study explores how memory and persistence can be implemented in another model class, derivative feedback networks. We show that these networks can operate with two vastly different time courses, changing their state quickly when new information is coming in but retaining it for a long time, and that these capabilities are robust to short-term depression. Specifically, derivative feedback networks with short-term depression that acts differentially on positive and negative feedback projections are capable of dynamically changing their time constant, thus allowing fast onset and slow decay of responses without requiring unrealistically large input transients.


Related Articles

  • EFFECTS OF SENSORY FEEDBACK ON VARIATIONS OF INTERTAP INTERVAL AND FORCE IN FINGER-TAPPING... Inui, Nobuyuki; Ishida, Toshiko; Katsura, Yumi // Perceptual & Motor Skills;Jun2001 Part 1, Vol. 92 Issue 3, p795 

    Examines effects of somatosensory feedback on variations of intertap and muscle force in finger-tapping sequences. Comparison of intertap intervals and peak forces on the massed task with those in the distributed task; Positive and negative correlations between spontaneous variations in...

  • EL LABERINTO DE LA SOMATIZACI�N: SE BUSCAN SALIDAS. L�PEZ-SANTIAGO, JOS�; BELLOCH, AMPARO // Revista de Psicopatologia y Psicologia Clinica;ago2012, Vol. 17 Issue 2, p151 

    Somatization disorder (SD) was included as a new syndrome in the DSM-III (APA, 1980), but its removal from the DSM-V as a diagnostic category is more than probable. This work examines the main studies that SD has generated in the last 30 years as regards epidemiology, comorbidity, and associated...

  • Continuous theta-burst stimulation modulates tactile synchronization. Lee, Kevin G.H.; Jacobs, Mark F.; Asmussen, Michael J.; Zapallow, Christopher M.; Tommerdahl, Mark; Nelson, Aimee J. // BMC Neuroscience;2013, Vol. 14 Issue 1, p1 

    Background: Temporal order judgement (TOJ) is the ability to detect the order of occurrence of two sequentially delivered stimuli. Previous research has shown that TOJ in the presence of synchronized periodic conditioning stimuli impairs TOJ performance, and this phenomenon is suggested to be...

  • Plasticity-Inducing TMS Protocols to Investigate Somatosensory Control of Hand Function. Jacobs, M.; Premji, A.; Nelson, A. J. // Neural Plasticity;2012, Vol. 2012, Special section p1 

    Hand function depends on sensory feedback to direct an appropriate motor response. There is clear evidence that somatosensory cortices modulate motor behaviour and physiology within primary motor cortex. However, this information is mainly from research in animals and the bridge to human hand...

  • Mindfulness starts with the body: somatosensory attention and top-down modulation of cortical alpha rhythms in mindfulness meditation. Kerr, Catherine E.; Sacchet, Matthew D.; Lazar, Sara W.; Moore, Christopher I.; Jones, Stephanie R. // Frontiers in Human Neuroscience;Feb2013, Vol. 7, p1 

    Using a common set of mindfulness exercises, mindfulness based stress reduction (MBSR) and mindfulness based cognitive therapy (MBCT) have been shown to reduce distress in chronic pain and decrease risk of depression relapse. These standardized mindfulness (ST-Mindfulness) practices...

  • Aberrant topology of striatum’s connectivity is associated with the number of episodes in depression. Meng, Chun; Brandl, Felix; Tahmasian, Masoud; Shao, Junming; Manoliu, Andrei; Scherr, Martin; Schwerthöffer, Dirk; Bäuml, Josef; Förstl, Hans; Zimmer, Claus; Wohlschläger, Afra M.; Riedl, Valentin; Sorg, Christian // Brain: A Journal of Neurology;Feb2014, Vol. 137 Issue 2, p598 

    In major depression, endogenous factors that determine relapse frequency remain poorly understood. Meng et al. applied resting-state functional MRI and graph-based network analysis to study the link between the number of episodes and functional brain network connectivity. They report an...

  • Ovariectomy Results in Variable Changes in Nociception, Mood and Depression in Adult Female Rats. Li, Li-Hong; Wang, Zhe-Chen; Yu, Jin; Zhang, Yu-Qiu // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Decline in the ovarian hormones with menopause may influence somatosensory, cognitive, and affective processing. The present study investigated whether hormonal depletion alters the nociceptive, depressive-like and learning behaviors in experimental rats after ovariectomy (OVX), a common method...

  • Computerized Dynamic Posturography in Patients with Diabetic Peripheral Neuropathy and Visual Feedback-Based Balance Training Effects. Ahmed, Mohieldin M.; Mosalem, Douaa M.; Tarshouby, Wafaa A.; Alfeeli, Aziz K.; Baqer, Ayyoub B.; Mohamed, Mohamed H. // Macedonian Journal of Medical Sciences;Jun 2014, Vol. 7 Issue 2, p271 

    BACKGROUND: Diabetic peripheral neuropathy (DPN) often has reduced stability during standing conditions. AIM: To compare balance control in diabetic patients and normal subjects using computerized dynamic posturography and to assess effect of visual feedback-based balance training in DPN....

  • Learning from negative feedback in patients with major depressive disorder is attenuated by SSRI antidepressants. Herzallah, Mohammad M.; Moustafa, Ahmed A.; Natsheh, Joman Y.; Abdellatif, Salam M.; Taha, Mohamad B.; Tayem, Yasin I.; Sehwail, Mahmud A.; Amleh, Ivona; Petrides, Georgios; Myers, Catherine E.; Gluck, Mark A. // Frontiers in Integrative Neuroscience;Sep2013, Vol. 7, p1 

    One barrier to interpreting past studies of cognition and major depressive disorder (MDD) has been the failure in many studies to adequately dissociate the effects of MDD from the potential cognitive side effects of selective serotonin reuptake inhibitors (SSRIs) use. To better understand how...

  • Getting Out Of A Funk. Besednjak, Frank // IE3;Mar2014, Vol. 3 Issue 2, p56 

    The article offers tips for getting out of a feeling of funk. Topics include making a plan of action with short term goals, asking for help on tasks that one cannot do and for constructive feedback from colleagues and friends, and realizing that there are things that are out of one's control....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics