TITLE

Effect of temperature on FAD and NADH-derived signals and neurometabolic coupling in the mouse auditory and motor cortex

AUTHOR(S)
Ibrahim, Baher; Wang, Huan; Lesicko, Alexandria; Bucci, Bethany; Paul, Kush; Llano, Daniel
PUB. DATE
December 2017
SOURCE
Pflugers Archiv European Journal of Physiology;Dec2017, Vol. 469 Issue 12, p1631
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Tight coupling of neuronal metabolism to synaptic activity is critical to ensure that the supply of metabolic substrates meets the demands of neuronal signaling. Given the impact of temperature on metabolism, and the wide fluctuations of brain temperature observed during clinical hypothermia, we examined the effect of temperature on neurometabolic coupling. Intrinsic fluorescence signals of the oxidized form of flavin adenine dinucleotide (FAD) and the reduced form of nicotinamide adenine dinucleotide (NADH), and their ratios, were measured to assess neural metabolic state and local field potentials were recorded to measure synaptic activity in the mouse brain. Brain slice preparations were used to remove the potential impacts of blood flow. Tight coupling between metabolic signals and local field potential amplitudes was observed at a range of temperatures below 29 °C. However, above 29 °C, the metabolic and synaptic signatures diverged such that FAD signals were diminished, but local field potentials retained their amplitude. It was also observed that the declines in the FAD signals seen at high temperatures (and hence the decoupling between synaptic and metabolic events) are driven by low FAD availability at high temperatures. These data suggest that neurometabolic coupling, thought to be critical for ensuring the metabolic health of the brain, may show temperature dependence, and is related to temperature-dependent changes in FAD supplies.
ACCESSION #
126260355

 

Related Articles

  • Visual task enhances spatial selectivity in the human auditory cortex. Salminen, Nelli H.; Aho, Joanna; Sams, Mikko // Frontiers in Systems Neuroscience;Mar2013, Vol. 7, p1 

    The auditory cortex represents spatial locations differently from other sensory modalities. While visual and tactile cortices utilize topographical space maps, for audition no such cortical map has been found. Instead, auditory cortical neurons have wide spatial receptive fields and together...

  • NADH supplementation may improve energy, health. Sahelin, Ray // Better Nutrition;Jun98, Vol. 60 Issue 6, p36 

    Reports on the introduction of nicotinamide adenine dinucleotide (NADH) a nutrient which stimulates brain function. Identification of foods which NADH is found in; Reference to the content of NADH in fruits and vegetables; How NADH produces energy; Details on research of NADH; What are the side...

  • Facing the Music: Musicianship's Effect on the Brain. Kraus, Nina // Canadian Hearing Report;2013, Vol. 8 Issue 2, p21 

    The article discusses the effects of music training on the brain. It mentions one example of neurological changes in the brain when having music training such as the reorganization of motor cortex which happens to string-instrument players. It states examples of changes in the brain of musicians...

  • A synaptic and circuit basis for corollary discharge in the auditory cortex. Schneider, David M.; Nelson, Anders; Mooney, Richard // Nature;9/11/2014, Vol. 513 Issue 7517, p189 

    Sensory regions of the brain integrate environmental cues with copies of motor-related signals important for imminent and ongoing movements. In mammals, signals propagating from the motor cortex to the auditory cortex are thought to have a critical role in normal hearing and behaviour, yet the...

  • Adaptation in the auditory system: an overview. Pérez-González, David; Malmierca, Manuel S. // Frontiers in Integrative Neuroscience;Mar2014, Vol. 8, p1 

    The early stages of the auditory system need to preserve the timing information of sounds in order to extract the basic features of acoustic stimuli. At the same time, different processes of neuronal adaptation occur at several levels to further process the auditory information. For instance,...

  • Auditory Rehabilitation in the Digital Age. McSpaden, Jay B.; Brethower, Lawrence D. // Hearing Review;Dec2008, Vol. 15 Issue 13, p20 

    The article features digital signal processing (DSP) hearing instruments as a step to processing acoustic energy and hearing through amplification. According to the article, DSP eases the establishment of the intensity-specific residual auditory area of the patient. It advocates a counseling...

  • Objective and subjective indexes of auditory motion processing. Shestopalova, L.; Petropavlovskaia, E.; Vaitulevich, S.; Nikitin, N. // Human Physiology;May2014, Vol. 40 Issue 3, p265 

    The objective and subjective indexes of sound stimulus discrimination have been studied in order to get insight into individual stages of signal processing in the human brain. The experiment employed two methods: electrophysiological (mismatch negativity or MMN recording) and psychophysical...

  • Effect of 1 Hz Repetitive Transcranial Magnetic Stimulation Over the Auditory Cortex on Audiometry and Otoacustic Emissions. Schönfeldt-Lecuona, C.; Cárdenas-Morales, L.; Moreno-Aguirre, A.; Dorn, K.; Langguth, B.; Brühl, A.; Kammer, T.; Herwig, U. // Brain Topography;Jul2012, Vol. 25 Issue 3, p241 

    Repetitive transcranial magnetic stimulation (rTMS) at low frequencies (≤1 Hz) delivered to the primary motor cortex for 15 min or longer has been shown to reduce motor cortex excitability. Over the visual cortex, 1 Hz rTMS led to increased phosphene thresholds and over the auditory cortex...

  • The Chemistry of Nicotinamide Adenine Dinucleotide (NAD) Analogues Containing C-Nucleosides Related to Nicotinamide Riboside [1]. Pankiewicz, Krzysztof W.; Watanabe, Kyoichi A.; Lesiak-Watanabe, Krystyna; Goldstein, Barry M.; Jayaram, Hiremagalur N. // Current Medicinal Chemistry;Apr2002, Vol. 9 Issue 7, p733 

    Oncolytic C-nucleosides, tiazofurin (2-�-D-ribofuranosylthiazole-4- carboxamide) and benzamide riboside (3-�-D-ribofuranosylbenzamide) are converted in cell into active metabolites thiazole-4-carboxamide- and benzamide adenine dinucleotide, TAD and BAD, respectively. TAD and BAD as NAD...

  • NOX enzymes in immuno-inflammatory pathologies. Krause, Karl-Heinz; Bedard, Karen // Seminars in Immunopathology;2008, Vol. 30 Issue 3, p193 

    The article introduces the topic of the issue, which discusses research into nicotinamide adenine dinucleotide phosphate oxidase (NOX) enzymes.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics