TITLE

Elevated Concentrations of CCL2 and Tumor Necrosis Factor--α in Chagasic Cardiomyopathy

AUTHOR(S)
Talvani, André; Rocha, Manoel O. C.; Barcelos, Lucíola S.; Gomes, Yara M.; Ribeiro, Antônio L.; Teixeira, Mauro M.
PUB. DATE
April 2004
SOURCE
Clinical Infectious Diseases;4/1/2004, Vol. 38 Issue 7, p943
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Chronic myocarditis is the main pathological finding associated with Chagas disease-related morbidity. Concentrations of CCL2, CCL3, tumor necrosis factor (TNF)-α, and brain natriuretic peptide (BNP) were evaluated in plasma samples obtained from patients with different clinical forms of chronic chagasic cardiomyopathy. Patients with more-severe Chagas disease had elevated plasma concentrations of TNF-α, CCL2, and BNP, and there was a good correlation between levels of these proteins (especially TNF-α) and the degree of heart dysfunction. Indeed, TNF-α level was an excellent predictor of heart failure. Peripheral blood mononuclear cell samples obtained from patients with mild or severe chagasic cardiomyopathy produced greater amounts of TNF-α and CCL2 than did those obtained from noninfected individuals. The elevation of TNF-α and CCL2 levels in the plasma of patients appears to be secondary to the degree of heart dysfunction, whereas spontaneous production of TNF-α and CCL2 by mononuclear cells is secondary not only to heart dysfunction, but also to the underlying inflammation in the heart of chagasic patients. Measurement of the TNF-α level could be a useful tool in the identification of patients with heart dysfunction who may benefit from further investigation and treatment.
ACCESSION #
12600892

 

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