Elevated Concentrations of CCL2 and Tumor Necrosis Factor--α in Chagasic Cardiomyopathy

Talvani, André; Rocha, Manoel O. C.; Barcelos, Lucíola S.; Gomes, Yara M.; Ribeiro, Antônio L.; Teixeira, Mauro M.
April 2004
Clinical Infectious Diseases;4/1/2004, Vol. 38 Issue 7, p943
Academic Journal
Chronic myocarditis is the main pathological finding associated with Chagas disease-related morbidity. Concentrations of CCL2, CCL3, tumor necrosis factor (TNF)-α, and brain natriuretic peptide (BNP) were evaluated in plasma samples obtained from patients with different clinical forms of chronic chagasic cardiomyopathy. Patients with more-severe Chagas disease had elevated plasma concentrations of TNF-α, CCL2, and BNP, and there was a good correlation between levels of these proteins (especially TNF-α) and the degree of heart dysfunction. Indeed, TNF-α level was an excellent predictor of heart failure. Peripheral blood mononuclear cell samples obtained from patients with mild or severe chagasic cardiomyopathy produced greater amounts of TNF-α and CCL2 than did those obtained from noninfected individuals. The elevation of TNF-α and CCL2 levels in the plasma of patients appears to be secondary to the degree of heart dysfunction, whereas spontaneous production of TNF-α and CCL2 by mononuclear cells is secondary not only to heart dysfunction, but also to the underlying inflammation in the heart of chagasic patients. Measurement of the TNF-α level could be a useful tool in the identification of patients with heart dysfunction who may benefit from further investigation and treatment.


Related Articles

  • A randomized trial of the effects of exercise training in Chagas cardiomyopathy. Lima, Márcia M. O.; Rocha, Manoel Otávio C.; Nunes, Maria Carmo P.; Sousa, Lidiane; Costa, Henrique S.; Alencar, Maria Clara N.; Britto, Raquel R.; Ribeiro, Antonio Luiz P. // European Journal of Heart Failure;Aug2010, Vol. 12 Issue 8, p866 

    Aims: The effects of exercise training in chronic heart failure are well established, however, they have not been evaluated in Chagas cardiomyopathy (ChC). We sought to determine the effects of exercise training on functional capacity, health-related quality of life (HQoL), and brain natriuretic...

  • Chemokine Receptor Expression on the Surface of Peripheral Blood Mononuclear Cells in Chagas Disease. Talvani, Andre; Rocha, Manoel O. C.; Ribeiro, Antonio L.; Correa-Oliveira, Rodrigo; Teixeira, Mauro M. // Journal of Infectious Diseases;1/15/2004, Vol. 189 Issue 2, p214 

    We evaluated the expression of chemokine receptors (CCR1, CCR2, CCR5, and CXCR4) on the surface of peripheral blood mononuclear cells obtained from patients with chronic chagasic cardiomyopathy (CCC) and noninfected individuals. Only CCR5 and CXCR4 expression was different on the surface of the...

  • Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy. Shamim Ahmad; Parminder Otaal; Taranjit Rai; Ajay Bahl; Uma Saikia; Rohit Manoj; M. Thungapathra; Kewal Talwar; Madhu Khullar // Molecular & Cellular Biochemistry;Apr2009, Vol. 324 Issue 1/2, p139 

    Abstract   Background Increased levels of TNF-α, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and...

  • BNP�Considering a Heartfelt Message. Sikaris, Ken // Heart, Lung & Circulation;Sep2004 Supplement 3, Vol. 13, pS31 

    The natriuretic hormones have been discovered as mediators of the cardiac response to volume overload and mechanical dysfunction. Although there are some physiological differences between atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), it is BNP that has been found to be...

  • GP judgment beats BNP.  // Pulse;3/5/2008, Vol. 68 Issue 8, p3 

    The article reports on the result of the study on the B-type natriuretic peptide (BPN) testing in patients with suspected heart failure. The study suggests that general practitioners would do better relying on their clinical judgment than BNP testing. According to the study, BNP testing...

  • New Investigational Drugs for the Management of Acute Heart Failure Syndromes. Tamargo, J.; Amoros, I.; Barana, A.; Caballero, R.; Delpon, E. // Current Medicinal Chemistry;Feb2010, Vol. 17 Issue 4, Special section p1 

    Acute heart failure syndromes (AHFS) enclose a broad spectrum of conditions with different clinical presentations, heart failure history, pathophysiology, prognosis and treatment. AHFS represent a major public health problem because of their high prevalence, high rates of mortality and...

  • How well does B-type natriuretic peptide predict death and cardiac events in patients with heart failure: systematic review. Doust, J. A.; Pietrzak, E.; Dobson, A.; Glasziou, P. P. // BMJ: British Medical Journal (International Edition);3/19/2005, Vol. 330 Issue 7492, p625 

    The objective: to assess how well B-type natriuretic peptide (BNP) predicts prognosis in patients with heart failure. Design: Systematic review of studies assessing BNP for prognosis in patients with heart failure or asymptomatic patients. Data sources: Electronic searches of Medline and Embase...

  • The role of plasma biomarkers in acute heart failure. Serial changes and independent prognostic value of NT-proBNP and cardiac troponin-T. Metra, Marco; Nodari, Savina; Parrinello, Giovanni; Specchia, Claudia; Brentana, Loretta; Rocca, Patrizia; Fracassi, Francesco; Bordonali, Tania; Milani, Patrizia; Danesi, Rossella; Verzura, Giulia; Chiari, Ermanna; Dei Cas, Livio // European Journal of Heart Failure;Aug2007, Vol. 9 Issue 8, p776 

    Abstract: Aims: Brain natriuretic peptide (BNP), NT-proBNP and troponins are useful for the assessment of patients with heart failure. Few data exist about their serial changes and their prognostic value in patients with acute heart failure (AHF). Methods and results: NT-proBNP and troponin-T...

  • Relationship between renal function and serum cardiac troponin T in patients with chronic heart failure. Tsutamoto, Takayoshi; Kawahara, Chiho; Yamaji, Masayuki; Nishiyama, Keizo; Fujii, Masanori; Yamamoto, Takashi; Horie, Minoru // European Journal of Heart Failure;Jul2009, Vol. 11 Issue 7, p653 

    Aims: Both serum cardiac troponin T (cTnT) and renal function are prognostic predictors in patients with chronic heart failure (CHF). We aimed to evaluate the relationship between renal function and serum cTnT.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics