Review: Prophylactic use of β-carotene may increase the risk for all-cause mortality and cardiovascular death: COMMENTARY

Tea, Koon K.
March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p45
Academic Journal
The article comments on a study conducted to examine the efficiency of antioxidant vitamins in primary and secondary prevention of the all-cause mortality and cardiovascular (CVD) events. The physiologic basis for using antioxidant therapy to modify development of atherosclerosis appears logical and has much appeal to the public and health care providers. The meta-analysis of large randomized controlled trials of the study showed that despite the enhanced statistical power offered by the overall data, use of vitamin E did not have any beneficial effects and that β-carotene was associated with a slight but significant increase in risk for all-cause and CDV mortality.


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