Review: Prophylactic acetylcysteine reduces contrast nephropathy in chronic renal insufficiency

March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p41
Academic Journal
The article examines if prophylactic acetylcysteine with hydration reduce the incidence of contrast nephropathy more than hydration alone in patients with chronic renal insufficiency. Studies were selected if they were randomized, placebo-controlled trials published in any language that evaluated acetylcysteine to prevent contrast nephropathy in patients with chronic renal insufficiency receiving contrast media for diagnostic or therapeutic procedures. It was found that in patients with chronic renal insufficiency, adding prophylactic acetylcysteine to hydration reduces the incidence of contrast nephropathy more than hydration alone.


Related Articles

  • Concomitant drugs with exposure to contrast media. Erley, C. // Kidney International Supplement;Apr2006, Issue 100, pS20 

    The increasing number of radiological procedures performed in old patients with high co-morbidity may be one of the problems physicians have to deal with when regarding the increasing number of acute renal failures. A key question when addressing the patients scheduled to receive iodinated...

  • Prevention of contrast-induced nephropathy with volume supplementation. Mueller, C. // Kidney International Supplement;Apr2006, Issue 100, pS16 

    Volume supplementation remains the cornerstone for the prevention of contrast-induced nephropathy (CIN). Current evidence suggests that the combination of intravenous and oral volume supplementation effectively prevents CIN in low- and moderate-risk patients. Normal isotonic (0.9%) saline should...

  • Contrast-induced nephropathy: Definition, epidemiology, and patients at risk. Mehran, R.; Nikolsky, E. // Kidney International Supplement;Apr2006, Issue 100, pS11 

    Radiological procedures utilizing intravascular iodinated contrast media injections are being widely applied for both diagnostic and therapeutic purposes. This has resulted in an increasing incidence of procedure-related contrast-induced nephropathy (CIN). The definition of CIN includes absolute...

  • Contrast medium-induced nephropathy: The pathophysiology. Persson, P. B.; Tepel, M. // Kidney International Supplement;Apr2006, Issue 100, pS8 

    A widespread, rather general, definition of contrast-induced nephropathy (CIN) is an impairment in renal function occurring within 3 days following the intravascular administration of contrast media (CM) and the absence of an alternative aetiology. In spite of the vast clinical importance of...

  • Contrast-induced nephrotoxicity: Clinical landscape. Katzberg, R. W.; Haller, C. // Kidney International Supplement;Apr2006, Issue 100, pS3 

    Over 80 million doses of iodinated intravascular contrast media (CM) were administered in the most recent tabulations of 2003, corresponding to approximately 8 million liters, making it one of the highest volume medical drugs used compared to any other pharmaceutical. The evolution of CM has...

  • COMPARISON OF DIFFERENT AGENTS ON RADIOGRAPHIC CONTRAST AGENT INDUCED NEPHROPATHY. Demir, Murat; Kutlucan, Ali; Akın, Huseyin; Aydın, Osman; Sezer, Mehmet Tugrul // European Journal of General Medicine;2008, Vol. 5 Issue 4, p222 

    Aim: Nephropathy induced by contrast media (CM) still a problem in clinical practice and a variety of therapeutic interventions have been used in an attempt to prevent radiocontrast-induced nephropathy. However most of the published reports are placebo controlled studies and especially in...

  • Mezzi di contrasto in radiologia urologica. Foschi, N.; Totaro, A.; Brescia, A.; Gulino, G.; Bassi, P. F. // Urologia;2009, Vol. 76 Issue 1, p10 

    BACKGROUND. Contrast media are widely used in urogenital radiology. The ideal contrast agent should be totally inert, causing no interactions with organism, and with a rapid and complete excretion. Adverse reactions could occur after using any type of contrast media. Contrast enhanced procedures...

  • Nephrotoxicity of contrast media. Berns, Arnold S. // Kidney International;Oct1989, Vol. 36 Issue 4, p730 

    Focuses on the role of nephrology in the cause of renal failure. Influence of radiocontrast agents on the episodes of renal failure; Factors identified that increase the risk of contrast-associated nephrotoxicity; Prevalence of such risk factors upon the onset of the disease.

  • ASSESSMENT AND PREVENTION OF CONTRAST INDUCED AKI IN CKD.  // Indian Journal of Nephrology;Sep2014 Supplement, Vol. 24 Issue S1, pS14 

    The article discusses the prevention and assessment of contrast-induced acute kidney injury (CI-AKI) in chronic kidney disease (CKD). Topics covered include the use of alternative imaging methods in patients with higher risk for CI-AKI, intravascular volume expansion, and the use of fenoldapam...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics