Clarithromycin, lansoprazole, and metronidazole eradicated H. pylori infection in chronic renal insufficiency

March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p40
Academic Journal
The article examines if triple therapy consisting of clarithromycin, lansoprazole, and metronidazole (CLM) is more effective than one consisting of clarithromycin, lansoprazole, and a reduced dosage of amoxicillin (CLA) for eradicating Helicobacter pylori in patients with dyspepsia and chronic renal insufficiency. 88 patients with dyspepsia who had chronic renal insufficiency and H. pylori infection were analysed in a hospital. 44 patients each were allocated to CLM or CLA and amoxicillin 750, twice daily for 1 week. The rates of successful H. pylori eradication and complete drug compliance were greater in the CLM group than in the CLA group.


Related Articles

  • Clarithromycin, lansoprazole, and metronidazole eradicated H. pylori infection in chronic renal insufficiency: COMMENTARY. Lew, Edward A. // ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p40 

    The article comments on a study conducted to examine triple therapy for Helicobacter pylori eradication in chronic renal insufficiency. The study compared a metronidazole-clarithromycin-based regimen (CLM) with an amoxicillin-clarithromycin-based regimen (CLA) for eradicating H. pylori in...

  • Gastric emptying improves after installing hemodialysis in uremic patients.  // Kidney;Sep/Oct2002, Vol. 11 Issue 5, p214 

    Presents a summary of the study 'Dyspepsia and Gastroparesis in Chronic Renal Failure: The Role of Helicobacter pylori,' by R. Schoonjans, B. Van Vlem et al., from a 2002 issue of 'Clinical Nephrology.'

  • Editorials. Graham, David Y.; Börsch, Gereon M. A. // American Journal of Gastroenterology;Dec1990, Vol. 85 Issue 12, p1552 

    Presents information on the treatment of helicobacter pylori infections. Effectiveness of topical therapy in the stomach in treating helicobacter pylori infections; Difference between killing H. pylori and eradicating the infection; Results of initial attempts at combination therapy such as...

  • Variability with Omeprazole--Amoxicillin Combinations for Treatment of Helicobacter pylori Infection. Graham, Kathleen S.; Malaty, Hoda; El-Zimaity, Hala M. T. // American Journal of Gastroenterology;Sep1995, Vol. 90 Issue 9, p1415 

    Objective: Although omeprazole co-therapy enhances the effectiveness of some antimicrobials for the treatment of Helicobacter pylori infection, results have not been uniform. A meta-analysis suggested that 20 mg of omeprazole b.i.d. and 2 g or more of amoxicillin would yield a >80% success rate...

  • Effect of Triple Therapy or Amoxycillin Plus Omeprazole or Amoxycillin Plus Tinidazole Plus Omeprazole on Duodenal Ulcer Healing, Eradication of Helicobacter pylori, and Prevention of Ulcer Relapse over a 1--Year Follow--Up Period: A Prospective,... Saberi-Firoozi, M.; Massarrat, S.; Zare, S.; Fattahi, M.; Javan, A.; Etaati, H.; Dehbashi, N. // American Journal of Gastroenterology;Sep1995, Vol. 90 Issue 9, p1419 

    Objectives: Triple therapy and amoxycillin plus omeprazole are the two most widely recommended regimens for the eradication of Helicobacter pylori. However, no controlled studies with a large number of cases are available for the reliable comparison of these two regimens. The aim of this...

  • Ä°lk basamak Helikobakter pilori eradikasyonunda levofloksasin temelli üçlü tedavinin etkinliÄŸi. Aydın, Yusuf; Nazlıgül, Yaşar; Yeniova, Abdullah Ö.; Kefeli, Ayşe; Şimşek, Gülçin; Saçıkara, Muhammed; Polat, Mehmet; Akkuş, İbrahim Halil // Dicle Medical Journal / Dicle Tip Dergisi;2011, Vol. 38 Issue 2, p197 

    Objectives: Standard triple therapy composed of a proton pump inhibitor, clarithromycin and amoxicillin has been widely preferred for H. pylori eradication in Turkey and World. Alternative therapies are currently under investigation because of an increase in clarithromycin resistance. The aim of...

  • Limited Efficacy of Omeprazole--based Dual and Triple Therapy for Helicobacter pylori: A Randomized Trial Employing "Optimal" Dosing. Laine, Loren; Stein, Craig; Neil, Garry // American Journal of Gastroenterology;Sep1995, Vol. 90 Issue 9, p1407 

    Objectives: To evaluate the efficacy and side effects of dual omeprazole/amoxicillin therapy for Helicobacter pylori given in "optimal" fashion (omeprazole twice a day, 3 g of amoxicllin daily, drugs started concurrently, 2 wk of therapy) and to assess the utility of adding a second antibiotic,...

  • Eradication therapy of Helicobacter pylori. A review. Unge, Peter // Journal of Gastroenterology;1998 Supplement 10, Vol. 33, p57 

    An expert meeting was organized by the Swedish and Norwegian Medical Products Agencies in September 1995 in order to review the current literature and opinions on detection and treatment of Helicobacter pylori. Ten people from these Agencies and 23 experts participated in the workshop and all...

  • One-day drug regimen for H pylori is effective. Polak, Monika // GP: General Practitioner;10/13/2003, p4 

    One-day quadruple therapy for Helicobacter pylori is as effective as the standard seven-day triple drug regimen, according to a U.S. research. Researchers randomly assigned 160 patients with dyspepsia, who had a positive urea breath test, to one of two groups. The researchers found that both...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics