High- and moderate-intensity warfarin regimens did not differ for preventing thrombosis in the antiphospholipid antibody syndrome

March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p38
Academic Journal
The article analyses if high-intensity warfarin more effective than moderate-intensity warfarin for preventing recurrent thrombosis in patients with previous arterial or venous thrombosis and the antiphospholipid antibody syndrome. 114 patients who had an objectively confirmed arterial or venous thrombosis and a positive test for antiphospholipid antibodies were examined. They were allocated to moderate-intensity warfarin or high-intensity warfarin with different ratio of doses. It was found that in patients with previous arterial or venous thrombosis and antiphospholipid antibody syndrome, high-intensity warfarin was not better than moderate-intensity warfarin for preventing recurrent thrombosis.


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