Conventional-intensity was more effective than low-intensity warfarin therapy for preventing recurrent venous thromboembolism: COMMENTARY

Beyth, Rebecca
March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p37
Academic Journal
The article comments on a study conducted to analyze effectiveness of conventional-intensity over low-intensity warfarin therapy for preventing recurrent venous (VTE) thromboembolism. In patients with unprovoked VTE who have received 3 months of vitamin K antagonists (VKAs) with a target international normalized ratio (INR) of 2.0 to 3.0, uncertainty exists about the intensity and duration of anticoagulation. The study has strengthened the evidence that lowering INR below 2.0 for extended secondary prophylaxis results in more recurrences without diminishing the risk for bleeding.


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