Perindopril reduced cardiac events in stable coronary artery disease: COMMENTARY

Best, Patricia J. M.; Berger, Peter R.
March 2004
ACP Journal Club;Mar/Apr2004, Vol. 140 Issue 2, p31
Academic Journal
The article comments on the study of the efficacy of perindopril in reducing cardiac event in stable coronary artery diseases. The supported the widespread use of the angiotensin-converting enzyme (ACE ) inhibitor ramipril to prevent cardiovascular events. However, several questions remained and many physicians had reservations about changing practice based on a single, albeit large and well-designed, study. Even clinicians who believe that the benefits of ACE inhibitors are a class effect and not unique to tissue-specific ACE inhibitors acknowledge that the right dose and dosing strategy must be identified for each indication before it is assumed that all ACE inhibitors are equal.


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